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How to get fromCharleston to Fort Myersby bus, plane, train, or car

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There are 9 ways to get from Charleston to Fort Myers by bus, plane, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Ft. Myers, line 140 bus

    best
    1. Take the bus from Courtenay Dr / Doughty St to Fuel Farm Rd / Dreamliner Drbus bus
    2. Fly from Charleston International Airport (CHS) to Ft. Myers (RSW)plane plane CHS - RSW
    3. Take the bus from South Fort Myers Transfer/P&R to Edison Mall Transfer Ctrbus bus
    5h

  2. Drive 530.2 mi

    cheapest
    1. Drive from Charleston to Fort Myerscar car 530.2 mi
    9h 35m
    $97–140

  3. Train, bus via Jacksonville

    1. Take the train from Charleston Amtrak Station to Jacksonvilletrain train
    2. Take the bus from Jacksonville to Wildwood Amtrak Stationbus bus
    3. Take the bus from Wildwood to Fort Myersbus bus
    17h 20m
    $184–319

  4. Train, bus (Amtrak)

    1. Take the train from Charleston Amtrak Station to Orlandotrain train Silver Meteor
    2. Take the bus from Orlando to Fort Myers Amtrak Bus Stopbus bus Amtrak Thruway Connecting Service
    17h 31m
    $212–396

  5. Fly to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Charleston International Airport (CHS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane CHS - FLL
    2. Take the bus from Fort Lauderdale International Airport to Fort Myers Bus Stopbus bus
    6h 35m
    $191–1,070

  6. Fly to Tampa, bus

    1. Fly from Charleston International Airport (CHS) to Tampa (TPA)plane plane CHS - TPA
    2. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    8h 5m
    $167–370

  7. Fly to Miami International Airport, bus

    1. Fly from Charleston International Airport (CHS) to Miami International Airport (MIA)plane plane CHS - MIA
    2. Take the bus from Miami Airport Station to Fort Myers Bus Stopbus bus
    7h 34m
    $565–1,009

  8. Train, Amtrak Thruway, bus

    1. Take the train from Charleston Amtrak Station to Orlandotrain train
    2. Take the bus from Orlando, FL to Sarasota Amtrak Bus Stopbus bus
    3. Take the bus from Sarasota Cattlemen Transfer Center to Fort Myers Bus Stopbus bus
    18h 52m
    $187–360

  9. Train, bus #2

    1. Take the train from Charleston Amtrak Station to Delandtrain train
    2. Take the train from DeLand to LYNX Centraltrain train
    3. Take the bus from Orlando to Fort Myers Bus Stopbus bus
    19h 1m
    $154–311

Charleston to Fort Myers by bus and train

Calendar7Weekly Services
Duration18h 52mAverage Duration
Ticket$187Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Fort Myers.ExpandLaunch map view
  • Distance: 477.5 mi
  • Duration: 5h

What companies run services between Charleston, SC, USA and Fort Myers, FL, USA?

There is no direct connection from Charleston to Fort Myers. However, you can take the bus to Fuel Farm Rd / Dreamliner Dr, walk to Charleston-Airport-CHS airport, fly to Ft. Myers (RSW), walk to Rsw, take the line 50 bus to South Fort Myers Transfer/P&R, then take the line 140 bus to Edison Mall Transfer Ctr. Alternatively, you can take a bus from Mary St / Meeting St to Fort Myers via N. Charleston SuperStop, North Charleston Transit Center, Charleston Amtrak Station, Jacksonville, Jacksonville, Wildwood Amtrak Station, and Wildwood in around 17h 20m.

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