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How to get fromCharleston to Gainesvilleby train, bus, car, or plane

Find Transport to Gainesville

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There are 7 ways to get from Charleston to Gainesville by train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Charleston Amtrak Station to Jacksonvilletrain train Silver Meteor
    2. Take the bus from Jacksonville to Gainesvillebus bus FlixBus 2431
    8h 5m
    $123–228

  2. Drive 302.5 mi

    cheapest
    1. Drive from Charleston to Gainesvillecar car 302.5 mi
    5h 27m
    $56–80

  3. Fly Charleston International Airport to Gainesville Regional Airport

    1. Fly from Charleston International Airport (CHS) to Gainesville Regional Airport (GNV)plane plane CHS - GNV
    6h 5m
    $68–357

  4. Drive to Hilton Head Airport, fly to Gainesville Regional Airport

    1. Drive from Charleston to Hilton Head Airport (HHH)car car
    2. Fly from Hilton Head Airport (HHH) to Gainesville Regional Airport (GNV)plane plane HHH - GNV
    8h 4m
    $81–379

  5. Fly Charleston International Airport to Orlando, bus

    1. Fly from Charleston International Airport (CHS) to Orlando (MCO)plane plane CHS - MCO
    2. Take the bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Drbus bus
    6h 34m
    $96–300

  6. Fly Charleston International Airport to Jacksonville, bus

    1. Fly from Charleston International Airport (CHS) to Jacksonville (JAX)plane plane CHS - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    8h 54m
    $82–408

  7. Fly Charleston International Airport to Tampa, bus

    1. Fly from Charleston International Airport (CHS) to Tampa (TPA)plane plane CHS - TPA
    2. Take the bus from Tampa Bus Station to Gainesvillebus bus
    7h 35m
    $167–375

Charleston International Airport (CHS) to Gainesville Regional Airport (GNV) flights

Calendar55Weekly Planes
Duration4h 48mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Gainesville.ExpandLaunch map view
  • Distance: 331.5 mi
  • Duration: 8h 5m

What companies run services between Charleston, SC, USA and Gainesville, FL, USA?

Delta and American Airlines fly from Charleston International Airport (CHS) to Gainesville Regional Airport (GNV) every 4 hours.

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Train operators
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