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How to get fromCharleston to Gainesvilleby plane, bus, bus (Greyhound), train (Amtrak), car, or train

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There are 7 ways to get from Charleston to Gainesville by plane, bus, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Charleston International Airport, bus

    best
    1. Fly from Charleston International Airport (CHS) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane CHS - ATL
    2. Take the bus from Atlanta Bus Station to Gainesvillebus bus
    5h 18m
    $358–1,021

  2. Drive 277.8 mi

    cheapest
    1. Drive from Charleston to Gainesvillecar car 277.8 mi
    6h 5m
    $51–74

  3. Bus via Charlotte (Greyhound)

    1. Take the bus from Charleston Bus Station to Charlotte Bus Stationbus bus Greyhound US0643S
    2. Take the bus from Charlotte Bus Station to Gainesvillebus bus Greyhound US0670
    14h 22m
    $83–162

  4. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Selma Stationtrain train
    2. Take the train from Selma Station to Charlotte Amtrak Stationtrain train
    3. Take the train from Charlotte Amtrak Station to Gainesville Stationtrain train
    14h 55m
    $221–466

  5. Drive to Hilton Head Airport, fly, bus

    1. Drive from Charleston to Hilton Head Airport (HHH)car car
    2. Fly from Hilton Head Airport (HHH) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane HHH - ATL
    3. Take the bus from Atlanta Bus Station to Gainesvillebus bus
    6h 21m
    $95–439

  6. Bus, train

    1. Take the bus from Charleston Bus Station to Charlotte Bus Stationbus bus Greyhound US0643S
    2. Take the train from Charlotte Amtrak Station to Gainesville Stationtrain train Crescent
    15h 21m
    $106–235

  7. Bus

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta to BB Wireless - Gainesvillebus bus Charlotte
    16h 47m
    $116–289

Charleston to Gainesville by bus and train

Calendar7Weekly Services
Duration15h 21mAverage Duration
Ticket$106Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Gainesville.ExpandLaunch map view
  • Distance: 336.6 mi
  • Duration: 5h 18m

What companies run services between Charleston, SC, USA and Gainesville, GA, USA?

You can take a bus from Mary St / Meeting St to Gainesville via N. Charleston SuperStop, North Charleston Transit Center, Charleston Bus Station, Charlotte Bus Station, and Gainesville in around 14h 22m. Alternatively, you can take a vehicle from Charleston to Gainesville Station via Charleston Amtrak Station, Selma Station, and Charlotte Amtrak Station in around 14h 55m.

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