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How to get fromCharleston to Great Smoky Mountainsby plane, car, train, or bus

Find Transport to Great Smoky Mountains

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There are 8 ways to get from Charleston to Great Smoky Mountains by plane, car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport, drive

    best
    1. Fly from Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS)plane plane CHS - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 25m
    $111–641

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Charleston International Airport (CHS) to Asheville Regional Airport (AVL)plane plane CHS - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    6h 38m
    $60–324

  3. Train, bus, drive

    1. Take the train from Charleston Amtrak Station to Selma Stationtrain train
    2. Take the train from Selma Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    14h
    $169–331

  4. Bus, drive via Charlotte

    1. Take the bus from Charleston Bus Station to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    17h 17m
    $85–194

  5. Drive 332.5 mi

    1. Drive from Charleston to Great Smoky Mountainscar car 332.5 mi
    6h 14m
    $61–88

  6. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Charleston International Airport (CHS) to Greenville–Spartanburg International Airport (GSP)plane plane CHS - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Great Smoky Mountainscar car
    7h 35m
    $404–1,045

  7. Fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Charleston International Airport (CHS) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane CHS - ATL
    2. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    6h 40m
    $372–1,044

  8. Bus, drive (Greyhound)

    1. Take the bus from Charleston Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Asheville, NCbus bus
    3. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    19h 41m
    $103–199

Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS) flights

Calendar104Weekly Planes
Duration4h 20mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 373.5 mi
  • Duration: 6h 25m

What companies run services between Charleston, SC, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Charleston to Great Smoky Mountains. However, you can take the bus to Fuel Farm Rd / Dreamliner Dr, walk to Charleston-Airport-CHS airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a vehicle from Charleston to Great Smoky Mountains via Charleston Amtrak Station, Selma Station, Greensboro, Greensboro Bus Stop, and Asheville, NC in around 14h.

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