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How to get fromCharleston to Key Westby plane, train, bus, bus (Greyhound, Flixbus), car, or shuttle

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There are 6 ways to get from Charleston to Key West by plane, train, bus, bus (Greyhound, Flixbus), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Charleston International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Key West International Airport (EYW)plane plane CHS - EYW
    5h 13m
    $281–513

  2. Drive to Hilton Head Airport, fly

    cheapest
    1. Drive from Charleston to Hilton Head Airport (HHH)car car
    2. Fly from Hilton Head Airport (HHH) to Key West International Airport (EYW)plane plane HHH - EYW
    6h 51m
    $100–390

  3. Train, bus

    1. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    21h 42m
    $266–516

  4. Bus

    1. Take the bus from Charleston Bus Station to Savannah Bus Stationbus bus
    2. Take the bus from Savannah Bus Station to Miamibus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    23h 35m
    $135–238

  5. Drive 741.6 mi

    1. Drive from Charleston to Key Westcar car 741.6 mi
    13h 14m
    $136–196

  6. Train, bus, shuttle

    1. Take the train from Charleston Amtrak Station to West Palm Beach Amtrak Stationtrain train
    2. Take the bus from West Palm Beach, FL to Fort Lauderdale Airportbus bus
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key West, FLshuttle bus
    23h 8m
    $387–640

Charleston to Key West by bus, taxi, and foot

Calendar4Weekly Services
Duration23h 35mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Key West.ExpandLaunch map view
  • Distance: 598.6 mi
  • Duration: 5h 13m

What companies run services between Charleston, SC, USA and Key West, FL, USA?

American Airlines and Delta fly from Charleston International Airport (CHS) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a bus from Mary St / Meeting St to N Roosevelt & 3rd Street via N. Charleston SuperStop, North Charleston Transit Center, Charleston Bus Station, Savannah Bus Station, Miami, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 23h 35m.

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