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How to get fromCharleston to Key Westby plane, train, bus, car, or shuttle

Find Transport to Key West

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There are 5 ways to get from Charleston to Key West by plane, train, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Charleston International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Key West International Airport (EYW)plane plane CHS - EYW
    5h 57m
    $74–363

  2. Train, bus

    1. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    21h 42m
    $206–461

  3. Drive  741.6 mi

    1. Drive from Charleston to Key Westcar car 741.6 mi
    13h 14m
    $136–196

  4. Drive to Hilton Head Airport, fly

    1. Drive from Charleston to Hilton Head Airport (HHH)car car
    2. Fly from Hilton Head Airport (HHH) to Key West International Airport (EYW)plane plane HHH - EYW
    7h 31m
    $100–400

  5. Train, bus, shuttle

    1. Take the train from Charleston Amtrak Station to West Palm Beach Amtrak Stationtrain train
    2. Take the bus from West Palm Beach, FL to Fort Lauderdale Airportbus bus
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key West, FLshuttle bus
    23h 8m
    $337–594

Charleston to Key West by bus, train, and shuttle

Calendar7Weekly Services
Duration23h 8mAverage Duration
Ticket$337Cheapest Price
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Comparing Your Travel Options

Map of how to get from Charleston to Key West.ExpandLaunch map view
  • Distance: 598.6 mi
  • Duration: 5h 57m

What companies run services between Charleston, SC, USA and Key West, FL, USA?

Delta, American Airlines, and Breeze Airways fly from Charleston International Airport (CHS) to Key West International Airport (EYW) every 3 hours.

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