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How to get fromCharleston to Knoxvilleby plane, train, bus, taxi, shuttle, or car

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There are 5 ways to get from Charleston to Knoxville by plane, train, bus, taxi, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS)plane plane CHS - TYS
    4h 50m
    $146–621

  2. Drive 372.7 mi

    cheapest
    1. Drive from Charleston to Knoxvillecar car 372.7 mi
    6h 22m
    $68–99

  3. Train, bus, taxi, shuttle, drive

    1. Take the train from Charleston Amtrak Station to Washington Union Stationtrain train
    2. Take the bus from Washington Union Station to Bristol Exit 5 Park & Ride Lotbus bus
    3. Take the taxi from Bristol Exit 5 Park & Ride Lot to Black Bear Resorttaxi taxi
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Chilhowee at Holstoncar car
    26h 32m
    $464–676

  4. Train, bus

    1. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Palmetto / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    27h 58m
    $399–679

  5. Fly to Nashville, drive

    1. Fly from Charleston International Airport (CHS) to Nashville (BNA)plane plane CHS - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 38m
    $383–1,091

Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS) flights

Calendar104Weekly Planes
Duration4h 20mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Knoxville.ExpandLaunch map view
  • Distance: 327.1 mi
  • Duration: 4h 50m

What companies run services between Charleston, SC, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS) hourly.

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