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How to get fromCharleston to La Crosseby plane, train (Amtrak), car, train, or bus

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There are 7 ways to get from Charleston to La Crosse by plane, train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Charleston International Airport to La Crosse

    best
    1. Fly from Charleston International Airport (CHS) to La Crosse (LSE)plane plane CHS - LSE
    7h 3m
    $113–463

  2. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    35h 9m
    $506–1,066

  3. Drive 1,154.9 mi

    1. Drive from Charleston to La Crossecar car 1,154.9 mi
    20h 38m
    $211–305

  4. Drive to Hilton Head Airport, fly to La Crosse

    1. Drive from Charleston to Hilton Head Airport (HHH)car car
    2. Fly from Hilton Head Airport (HHH) to La Crosse (LSE)plane plane HHH - LSE
    10h 37m
    $133–500

  5. Fly Charleston International Airport to Minneapolis–Saint Paul International Airport, train

    1. Fly from Charleston International Airport (CHS) to Minneapolis–Saint Paul International Airport (MSP)plane plane CHS - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    8h 52m
    $168–659

  6. Fly Charleston International Airport to Dane County Regional Airport-Truax Field, bus

    1. Fly from Charleston International Airport (CHS) to Dane County Regional Airport-Truax Field (MSN)plane plane CHS - MSN
    2. Take the bus from Madison to La Crossebus bus
    9h 59m
    $171–700

  7. Train, bus

    1. Take the train from Charleston Amtrak Station to Baltimore Penn Stationtrain train
    2. Take the train from Baltimore Penn Station to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to La Crossebus bus
    2d
    $534–1,124

Charleston to La Crosse by bus and train

Calendar3Weekly Services
Duration2dAverage Duration
Ticket$534Cheapest Price
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Questions & Answers

Map of how to get from Charleston to La Crosse.ExpandLaunch map view
  • Distance: 990.1 mi
  • Duration: 7h 3m

What companies run services between Charleston, SC, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Charleston International Airport (CHS) to La Crosse (LSE) 4 times a day. Alternatively, you can take a vehicle from Charleston to La Crosse Amtrak Station via Charleston Amtrak Station, Petersburg Amtrak Station, and Chicago Union Station in around 35h 9m.

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