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How to get fromCharleston to Lake Cityby train, bus, car, or plane

Find Transport to Lake City

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There are 5 ways to get from Charleston to Lake City by train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Charleston Amtrak Station to Jacksonvilletrain train Silver Meteor
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus Greyhound US0760S
    7h 36m
    $116–227

  2. Drive 291.9 mi

    cheapest
    1. Drive from Charleston to Lake Citycar car 291.9 mi
    5h 13m
    $54–77

  3. Fly to Jacksonville, bus

    1. Fly from Charleston International Airport (CHS) to Jacksonville (JAX)plane plane CHS - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    8h 25m
    $80–407

  4. Fly to Orlando, bus

    1. Fly from Charleston International Airport (CHS) to Orlando (MCO)plane plane CHS - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    9h 12m
    $93–292

  5. Fly to Gainesville Regional Airport, bus

    1. Fly from Charleston International Airport (CHS) to Gainesville Regional Airport (GNV)plane plane CHS - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    9h 30m
    $76–371

Charleston International Airport (CHS) to Jacksonville (JAX) flights

Calendar90Weekly Planes
Duration4h 32mAverage Duration
Ticket$69Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Lake City.ExpandLaunch map view
  • Distance: 323.2 mi
  • Duration: 7h 36m

What companies run services between Charleston, SC, USA and Lake City, FL, USA?

There is no direct connection from Charleston to Lake City. However, you can take the taxi to Charleston Amtrak Station, take the train to Jacksonville, walk to Amtrak Station, take the line 4 bus to JRTC Bay H, walk to Jacksonville, then take the bus to Lake City Bus Station. Alternatively, you can drive from Charleston to Lake City in around 5h 13m.

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