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How to get fromCharleston to Lexingtonby plane, car, or bus (Greyhound)

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There are 5 ways to get from Charleston to Lexington by plane, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport, drive

    best
    1. Fly from Charleston International Airport (CHS) to Louisville International Airport (SDF)plane plane CHS - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    4h 39m
    $354–417

  2. Drive 514.5 mi

    cheapest
    1. Drive from Charleston to Lexingtoncar car 514.5 mi
    9h 39m
    $94–136

  3. Bus via Savannah

    1. Take the bus from Charleston Bus Station to Savannah Bus Stationbus bus
    2. Take the bus from Savannah to Atlantabus bus
    3. Take the bus from Atlanta Bus Station to Lexington Bus Stopbus bus
    19h

  4. Fly to Blue Grass Airport

    1. Fly from Charleston International Airport (CHS) to Blue Grass Airport (LEX)plane plane CHS - LEX
    7h 12m
    $127–699

  5. Bus

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to Lexington Bus Stopbus bus Greyhound US0110
    22h 55m
    $161–296

Charleston International Airport (CHS) to Louisville International Airport (SDF) flights

Calendar64Weekly Planes
Duration3h 57mAverage Duration
Ticket$89Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Lexington.ExpandLaunch map view
  • Distance: 577.8 mi
  • Duration: 4h 39m

What companies run services between Charleston, SC, USA and Lexington, KY, USA?

You can take a bus from Mary St / Meeting St to Lexington via N. Charleston SuperStop, North Charleston Transit Center, Charleston Bus Station, Savannah Bus Station, Savannah, Atlanta Bus Station, and Lexington Bus Stop in around 19h. Alternatively, Delta, American Airlines, and United Airlines fly from Charleston International Airport (CHS) to Blue Grass Airport (LEX) hourly.

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