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How to get fromCharleston to Louisvilleby plane, bus (Greyhound), train, bus, or car

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There are 5 ways to get from Charleston to Louisville by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Louisville International Airport (SDF)plane plane CHS - SDF
    4h 21m
    $341–399

  2. Drive 581.2 mi

    cheapest
    1. Drive from Charleston to Louisvillecar car 581.2 mi
    11h 17m
    $107–154

  3. Bus

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville, IN to Louisville, KYbus bus
    26h 23m
    $169–319

  4. Train, bus (Amtrak)

    1. Take the train from Charleston Amtrak Station to Alexandriatrain train
    2. Take the train from Alexandria to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    31h 50m
    $433–881

  5. Fly to Blue Grass Airport, drive

    1. Fly from Charleston International Airport (CHS) to Blue Grass Airport (LEX)plane plane CHS - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 7m
    $136–717

Charleston to Louisville by bus

Calendar7Weekly Buses
Duration26h 23mAverage Duration
Ticket$169Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Louisville.ExpandLaunch map view
  • Distance: 504.5 mi
  • Duration: 4h 21m

What companies run services between Charleston, SC, USA and Louisville, KY, USA?

Breeze Airways, American Airlines, and three other airlines fly from Charleston International Airport (CHS) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a bus from Mary St / Meeting St to Louisville, KY via N. Charleston SuperStop, North Charleston Transit Center, Charleston Bus Station, Atlanta Bus Station, and Evansville, IN in around 26h 23m.

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