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How to get fromCharleston to Port Saint Lucieby plane, bus, train, or car

Find Transport to Port Saint Lucie

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There are 7 ways to get from Charleston to Port Saint Lucie by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Fort Lauderdale–Hollywood International Airport, bus

    best
    1. Fly from Charleston International Airport (CHS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane CHS - FLL
    2. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    6h 47m
    $200–1,080

  2. Drive 472.2 mi

    cheapest
    1. Drive from Charleston to Port Saint Luciecar car 472.2 mi
    8h 2m
    $87–125

  3. Train, bus via Buenaventura Lakes

    1. Take the train from Charleston Amtrak Station to Kissimmee Amtrak Stationtrain train Silver Meteor
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus Orlando to Miami
    14h 45m
    $166–326

  4. Fly to Miami International Airport, bus

    1. Fly from Charleston International Airport (CHS) to Miami International Airport (MIA)plane plane CHS - MIA
    2. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus bus
    7h 2m
    $573–1,010

  5. Fly to Orlando, bus

    1. Fly from Charleston International Airport (CHS) to Orlando (MCO)plane plane CHS - MCO
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    7h 21m
    $100–287

  6. Fly to President Donald J. Trump International Airport, bus

    1. Fly from Charleston International Airport (CHS) to President Donald J. Trump International Airport (PBI)plane plane CHS - PBI
    2. Take the bus from West Palm Beach Bus Station to Port St Luciebus bus
    7h 22m
    $123–751

  7. Train, bus

    1. Take the train from Charleston Amtrak Station to West Palm Beach Amtrak Stationtrain train Silver Meteor
    2. Take the bus from West Palm Beach Bus Station to Port St Luciebus bus FlixBus N2401 / ...
    15h 36m
    $228–450

Charleston to Port Saint Lucie by bus and train

Calendar7Weekly Services
Duration14h 45mAverage Duration
Ticket$166Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Port Saint Lucie.ExpandLaunch map view
  • Distance: 580 mi
  • Duration: 6h 47m

What companies run services between Charleston, SC, USA and Port Saint Lucie, FL, USA?

There is no direct connection from Charleston to Port Saint Lucie. However, you can take the bus to Fuel Farm Rd / Dreamliner Dr, walk to Charleston-Airport-CHS airport, fly to Fort Lauderdale–Hollywood International Airport (FLL), walk to Terminal 4, take the bus to Tri-Rail FLL Airport Station, walk to Fort Lauderdale Airport Station, take the train to Fort Lauderdale Station, walk to Fort Lauderdale - Broward Blvd Park and Ride, then take the bus to Fort Pierce. Alternatively, you can take a bus from Mary St / Meeting St to Fort Pierce via N. Charleston SuperStop, North Charleston Transit Center, Charleston Amtrak Station, Kissimmee Amtrak Station, Pleasant St & Neptune Rd, Osceola Pkwy Walmart, and Kissimmee -1471 East Osceola Parkway in around 14h 45m.

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