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How to get fromCharleston to Winston-Salemby train, bus, car, plane, or bus (Greyhound)

Find Transport to Winston-Salem

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There are 6 ways to get from Charleston to Winston-Salem by train, bus, car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Charleston Amtrak Station to Selma Stationtrain train
    2. Take the train from Selma Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    9h 11m
    $140–269

  2. Bus

    cheapest
    1. Take the bus from Charleston Bus Station to Charlotte Bus Stationbus bus Greyhound US0643S
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus Greyhound US0670
    11h 43m
    $51–129

  3. Train, bus via Fayetteville

    1. Take the train from Charleston Amtrak Station to Fayetteville Amtrak Stationtrain train Palmetto / ...
    2. Take the bus from Fayetteville Bus Station to Winston Salem(Trans Center)bus bus Greyhound US0647S
    10h 38m
    $82–159

  4. Drive 282.7 mi

    1. Drive from Charleston to Winston-Salemcar car 282.7 mi
    4h 54m
    $52–75

  5. Fly to Piedmont Triad International Airport

    1. Fly from Charleston International Airport (CHS) to Piedmont Triad International Airport (GSO)plane plane CHS - GSO
    5h 32m
    $338–1,297

  6. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Charleston International Airport (CHS) to Charlotte Douglas International Airport (CLT)plane plane CHS - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    5h 41m
    $70–456

Charleston to Winston-Salem by bus and train

Calendar14Weekly Services
Duration10h 38mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Winston-Salem.ExpandLaunch map view
  • Distance: 370.5 mi
  • Duration: 9h 11m

What companies run services between Charleston, SC, USA and Winston-Salem, NC, USA?

American Airlines, Delta, and United Airlines fly from Charleston International Airport (CHS) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Mary St / Meeting St to Winston Salem(Trans Center) via N. Charleston SuperStop, North Charleston Transit Center, Charleston Bus Station, and Charlotte Bus Station in around 11h 43m.

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