Rome2Rio

How to get fromCharleston to Mayo Clinicby plane, bus (Greyhound, Flixbus), train, bus, car, shuttle, or bus (Greyhound)

Find Transport to Mayo Clinic

See all options

There are 8 ways to get from Charleston to Mayo Clinic by plane, bus (Greyhound, Flixbus), train, bus, car, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Yeager Airport (CRW) to Rochester (RST)plane plane CRW - RST
    7h 42m
    $104–555

  2. Bus

    1. Take the bus from Charleston Bus Station to Columbusbus bus
    2. Take the bus from Columbus to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    21h 43m
    $160–278

  3. Train, bus via Madison

    1. Take the train from Charleston Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    24h 22m
    $241–478

  4. Drive 824.8 mi

    1. Drive from Charleston to Mayo Cliniccar car 824.8 mi
    14h 8m
    $151–218

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Yeager Airport (CRW) to Minneapolis–Saint Paul International Airport (MSP)plane plane CRW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 34m
    $185–717

  6. Fly to Mason City, bus, shuttle

    1. Fly from Yeager Airport (CRW) to Mason City (MCW)plane plane CRW - MCW
    2. Take the bus from Mason City to Owatonnabus bus
    3. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    13h 28m
    $140–645

  7. Bus via Chicago

    1. Take the bus from Charleston Bus Station to Columbusbus bus
    2. Take the bus from Columbus - Mound St to Chicagobus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    22h 33m
    $123–265

  8. Train, bus

    1. Take the train from Charleston Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    25h 20m
    $314–658

Charleston to Mayo Clinic by bus and foot

Calendar6Weekly Services
Duration21h 43mAverage Duration
Ticket$160Cheapest Price
See schedules

Questions & Answers

Map of how to get from Charleston to Mayo Clinic.ExpandLaunch map view
  • Distance: 696.8 mi
  • Duration: 7h 42m

What companies run services between Charleston, WV, USA and Mayo Clinic, MN, USA?

United Airlines, American Airlines, and Delta fly from Yeager Airport (CRW) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Charleston Bus Station to Mayo Clinic via Columbus, S Grant Ave & E Mound St, S High St & E Rich St, Columbus, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 21h 43m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers