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How to get fromCharlotte to Des Moinesby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Greyhound)

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There are 7 ways to get from Charlotte to Des Moines by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM)plane plane CLT - DSM
    3h 59m
    $189–873

  2. Bus via Columbus

    cheapest
    1. Take the bus from Charlotte Bus Station to Hurricanebus bus
    2. Take the bus from Hurricane to Columbus - Mound Stbus bus
    3. Take the bus from Columbus - Mound St to Chicagobus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    27h 40m
    $126–309

  3. Bus

    1. Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    26h 45m
    $194–373

  4. Train, bus

    1. Take the train from Charlotte Amtrak Station to Charlottesvilletrain train
    2. Take the train from Charlottesville to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    32h 41m
    $347–713

  5. Drive 1,030 mi

    1. Drive from Charlotte to Des Moinescar car 1,030 mi
    17h 42m
    $188–272

  6. Train, bus via Chicago

    1. Take the train from Charlotte Amtrak Station to Carytrain train
    2. Take the train from Cary to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    36h 52m
    $454–958

  7. Train, bus via Galesburg

    1. Take the train from Charlotte Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    38h 15m
    $487–1,038

Charlotte to Des Moines by bus

Calendar7Weekly Buses
Duration26h 45mAverage Duration
Ticket$194Cheapest Price
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Questions & Answers

Map of how to get from Charlotte to Des Moines.ExpandLaunch map view
  • Distance: 827.6 mi
  • Duration: 3h 59m

What companies run services between Charlotte, NC, USA and Des Moines, IA, USA?

American Airlines, Southwest Airlines, and two other airlines fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM) every 2 hours. Alternatively, you can take a bus from Charlotte Bus Station to Des Moines via Atlanta Bus Station and St Louis Bus Station in around 26h 45m.

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