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How to get fromCharlotte to Florenceby plane, bus (Flixbus, Greyhound), car, taxi, bus (Greyhound, Flixbus), or bus (Greyhound)

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There are 9 ways to get from Charlotte to Florence by plane, bus (Flixbus, Greyhound), car, taxi, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Alabama Regional Airport

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Northwest Alabama Regional Airport (MSL)plane plane CLT - MSL
    3h 22m
    $171–626

  2. Drive 463.1 mi

    cheapest
    1. Drive from Charlotte to Florencecar car 463.1 mi
    8h 44m
    $85–123

  3. Bus via Atlanta

    1. Take the bus from Charlotte Bus Station to Atlanta Downtownbus bus FlixBus N2470
    2. Take the bus from Atlanta Bus Station to Florencebus bus Greyhound US0622s
    12h 55m
    $99–173

  4. Fly to Huntsville International Airport-Carl T Jones Field, taxi

    1. Fly from Charlotte Douglas International Airport (CLT) to Huntsville International Airport-Carl T Jones Field (HSV)plane plane CLT - HSV
    2. Take the taxi from Huntsville International Airport-Carl T Jones Field (HSV) to Florencetaxi taxi
    4h 13m
    $222–662

  5. Fly to Birmingham–Shuttlesworth International Airport, drive

    1. Fly from Charlotte Douglas International Airport (CLT) to Birmingham–Shuttlesworth International Airport (BHM)plane plane CLT - BHM
    2. Drive from Birmingham-Airport-BHM to Florencecar car
    5h 5m
    $123–687

  6. Fly to Nashville, drive

    1. Fly from Charlotte Douglas International Airport (CLT) to Nashville (BNA)plane plane CLT - BNA
    2. Drive from Nashville-Airport-BNA to Florencecar car
    5h 34m
    $413–837

  7. Fly to Memphis, drive

    1. Fly from Charlotte Douglas International Airport (CLT) to Memphis (MEM)plane plane CLT - MEM
    2. Drive from Memphis-Airport-MEM to Florencecar car
    5h 54m
    $158–792

  8. Bus

    1. Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus bus Greyhound US0670 / ...
    2. Take the bus from Atlanta Bus Station to Florencebus bus Greyhound US0622s
    13h 15m
    $94–175

  9. Bus via Sandy Springs

    1. Take the bus from Charlotte to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Florencebus bus Greyhound US0622s
    16h 26m
    $122–280

Charlotte Douglas International Airport (CLT) to Northwest Alabama Regional Airport (MSL) flights

Calendar12Weekly Planes
Duration1h 45mAverage Duration
Ticket$155Cheapest Price
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Questions & Answers

Map of how to get from Charlotte to Florence.ExpandLaunch map view
  • Distance: 393.7 mi
  • Duration: 3h 22m

What companies run services between Charlotte, NC, USA and Florence, AL, USA?

Corporate Flight Management Inc flies from Charlotte Douglas International Airport (CLT) to Northwest Alabama Regional Airport (MSL) twice daily. Alternatively, you can take a bus from Charlotte Bus Station to Florence via Atlanta Downtown, Civic Center Station, Garnett Station, Atlanta Bus Station, and Florence in around 12h 55m.

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