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How to get fromCharlotte to Florida Keysby plane, bus, shuttle, train, car, or bus (Greyhound, Flixbus)

Find Transport to Florida Keys

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There are 8 ways to get from Charlotte to Florida Keys by plane, bus, shuttle, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Key West International Airport

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane plane CLT - EYW
    6h 35m
    $144–446

  2. Bus, shuttle

    1. Take the bus from Charlotte Bus Station to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Fort Lauderdale International Airportbus bus
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    21h 27m
    $285–377

  3. Bus, train

    1. Take the bus from Charlotte Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    28h 15m
    $527–849

  4. Drive  867.4 mi

    1. Drive from Charlotte to Florida Keyscar car 867.4 mi
    15h 3m
    $159–229

  5. Fly to Miami International Airport, shuttle

    1. Fly from Charlotte Douglas International Airport (CLT) to Miami International Airport (MIA)plane plane CLT - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 57m
    $284–886

  6. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Charlotte Douglas International Airport (CLT) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane CLT - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 23m
    $259–596

  7. Bus

    1. Take the bus from Charlotte Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    25h 40m
    $168–265

  8. Train, bus

    1. Take the train from Charlotte Amtrak Station to Carytrain train
    2. Take the train from Cary to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    32h 12m
    $634–1,052

Charlotte to Florida Keys by bus, foot, and shuttle

Calendar7Weekly Services
Duration21h 27mAverage Duration
Ticket$285Cheapest Price
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Comparing Your Travel Options

Map of how to get from Charlotte to Florida Keys.ExpandLaunch map view
  • Distance: 767.6 mi
  • Duration: 6h 35m

What companies run services between Charlotte, NC, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW) every 3 hours. Alternatively, you can take a bus from Charlotte Bus Station to Florida Keys via Fayetteville Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 25h 40m.

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