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How to get fromCharlotte to La Crosseby plane, bus (Greyhound, Amtrak), train (Amtrak), car, bus, or train

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There are 7 ways to get from Charlotte to La Crosse by plane, bus (Greyhound, Amtrak), train (Amtrak), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to La Crosse

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to La Crosse (LSE)plane plane CLT - LSE
    6h 24m
    $121–575

  2. Bus

    1. Take the bus from Charlotte Bus Station to Toledo Bus Stopbus bus
    2. Take the bus from Toledo to Chicago Union Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to La Crossebus bus
    26h 23m
    $242–412

  3. Train (Amtrak)

    1. Take the train from Charlotte Amtrak Station to Carytrain train
    2. Take the train from Cary to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    35h 12m
    $494–1,048

  4. Drive 1,023.1 mi

    1. Drive from Charlotte to La Crossecar car 1,023.1 mi
    17h 34m
    $187–270

  5. Fly to Dane County Regional Airport-Truax Field, bus

    1. Fly from Charlotte Douglas International Airport (CLT) to Dane County Regional Airport-Truax Field (MSN)plane plane CLT - MSN
    2. Take the bus from Madison to UW La Crossebus bus
    8h 26m
    $181–811

  6. Fly to Minneapolis–Saint Paul International Airport, train

    1. Fly from Charlotte Douglas International Airport (CLT) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLT - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    8h 33m
    $184–790

  7. Bus via Columbus

    1. Take the bus from Charlotte to Columbusbus bus
    2. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Chicagobus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to La Crossebus bus
    27h 3m

Charlotte to La Crosse by train (Amtrak)

Calendar7Weekly Trains
Duration35h 12mAverage Duration
Ticket$494Cheapest Price
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Questions & Answers

Map of how to get from Charlotte to La Crosse.ExpandLaunch map view
  • Distance: 826.2 mi
  • Duration: 6h 24m

What companies run services between Charlotte, NC, USA and La Crosse, WI, USA?

American Airlines flies from Charlotte Douglas International Airport (CLT) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from Charlotte Bus Station to La Crosse via Toledo, Chicago Union Station, W Jackson Blvd, after S Clinton St, and Madison in around 26h 23m.

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