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How to get fromCharlotte to Lake Cityby bus (Flixbus, Greyhound), car, plane, bus, or bus (Greyhound)

Find Transport to Lake City

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There are 7 ways to get from Charlotte to Lake City by bus (Flixbus, Greyhound), car, plane, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Charlotte Bus Station to Jacksonvillebus bus FlixBus 2433
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus Greyhound US0760S
    9h 30m
    $71–117

  2. Fly to Gainesville Regional Airport, bus

    cheapest
    1. Fly from Charlotte Douglas International Airport (CLT) to Gainesville Regional Airport (GNV)plane plane CLT - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    7h 48m
    $68–387

  3. Drive  433.1 mi

    1. Drive from Charlotte to Lake Citycar car 433.1 mi
    7h 24m
    $79–115

  4. Fly to Jacksonville, bus

    1. Fly from Charlotte Douglas International Airport (CLT) to Jacksonville (JAX)plane plane CLT - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    6h 34m
    $78–441

  5. Bus via Camden (Greyhound)

    1. Take the bus from Charlotte Bus Station to Camdenbus bus
    2. Take the bus from Camden to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    12h 10m
    $79–127

  6. Fly to Tallahassee, bus

    1. Fly from Charlotte Douglas International Airport (CLT) to Tallahassee (TLH)plane plane CLT - TLH
    2. Take the bus from Tallahassee to Lake City Bus Stationbus bus
    6h 37m
    $118–538

  7. Fly to Orlando, bus

    1. Fly from Charlotte Douglas International Airport (CLT) to Orlando (MCO)plane plane CLT - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    9h 32m
    $133–421

Charlotte to Lake City by bus

Calendar14Weekly Buses
Duration9h 30mAverage Duration
Ticket$71Cheapest Price
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Comparing Your Travel Options

Map of how to get from Charlotte to Lake City.ExpandLaunch map view
  • Distance: 443.6 mi
  • Duration: 9h 30m

What companies run services between Charlotte, NC, USA and Lake City, FL, USA?

You can take a bus from Charlotte Bus Station to Lake City Bus Station via Jacksonville in around 9h 30m.

Airlines
Bus operators

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