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How to get fromCharlotte to Mayo Clinicby plane, bus (Greyhound, Amtrak), train, bus, or car

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There are 7 ways to get from Charlotte to Mayo Clinic by plane, bus (Greyhound, Amtrak), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Rochester (RST)plane plane CLT - RST
    7h 52m
    $112–552

  2. Bus

    1. Take the bus from Charlotte Bus Station to Toledo Bus Stopbus bus
    2. Take the bus from Toledo to Chicago Union Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    28h 31m
    $257–432

  3. Train, bus via Madison

    1. Take the train from Charlotte Amtrak Station to Carytrain train
    2. Take the train from Cary to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    38h 57m
    $479–988

  4. Drive 1,088.1 mi

    1. Drive from Charlotte to Mayo Cliniccar car 1,088.1 mi
    18h 37m
    $199–287

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Charlotte Douglas International Airport (CLT) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLT - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 58m
    $194–754

  6. Bus via Columbus

    1. Take the bus from Charlotte to Columbusbus bus
    2. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Chicagobus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    29h 12m

  7. Train, bus

    1. Take the train from Charlotte Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    39h 53m
    $564–1,123

Charlotte to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration39h 53mAverage Duration
Ticket$564Cheapest Price
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Questions & Answers

Map of how to get from Charlotte to Mayo Clinic.ExpandLaunch map view
  • Distance: 875 mi
  • Duration: 7h 52m

What companies run services between Charlotte, NC, USA and Mayo Clinic, MN, USA?

American Airlines, Delta, and Sun Country Airlines fly from Charlotte Douglas International Airport (CLT) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Charlotte Bus Station to Mayo Clinic via Toledo, Chicago Union Station, W Jackson Blvd, after S Clinton St, Madison, and Rochester in around 28h 31m.

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