Rome2Rio

How to get fromCharlotte to Mayo Clinicby plane, bus (Greyhound, Amtrak), train, bus, or car

Find Transport to Mayo Clinic

See all options
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

There are 9 ways to get from Charlotte to Mayo Clinic by plane, bus (Greyhound, Amtrak), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Rochester (RST)plane plane CLT - RST
    7h 33m
    $93–512

  2. Bus

    1. Take the bus from Charlotte Bus Station to Toledo Bus Stopbus bus
    2. Take the bus from Toledo to Chicago Union Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    28h 46m

  3. Train, bus via Madison

    1. Take the train from Charlotte Amtrak Station to Carytrain train
    2. Take the train from Cary to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    38h 57m
    $716–1,220

  4. Drive  1,088.1 mi

    1. Drive from Charlotte to Mayo Cliniccar car 1,088.1 mi
    18h 35m
    $186–269

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Charlotte Douglas International Airport (CLT) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLT - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 21m
    $172–702

  6. Fly to The Eastern Iowa Airport, drive

    1. Fly from Charlotte Douglas International Airport (CLT) to The Eastern Iowa Airport (CID)plane plane CLT - CID
    2. Drive from Cedar-Rapids-Airport-CID to Mayo Cliniccar car
    7h 10m
    $111–497

  7. Fly to Dane County Regional Airport-Truax Field, bus

    1. Fly from Charlotte Douglas International Airport (CLT) to Dane County Regional Airport-Truax Field (MSN)plane plane CLT - MSN
    2. Take the bus from Madison to Rochesterbus bus
    10h 11m
    $134–519

  8. Bus via Columbus

    1. Take the bus from Charlotte to Columbusbus bus
    2. Take the bus from Columbus to Chicagobus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    29h 12m
    $154–310

  9. Train, bus

    1. Take the train from Charlotte Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    39h 46m
    $893–1,486

Charlotte Douglas International Airport (CLT) to Rochester (RST) flights

Calendar44Weekly Planes
Duration5h 43mAverage Duration
Ticket$91Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Charlotte to Mayo Clinic.ExpandLaunch map view
  • Distance: 875 mi
  • Duration: 7h 33m

What companies run services between Charlotte, NC, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and two other airlines fly from Charlotte Douglas International Airport (CLT) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Charlotte Bus Station to Mayo Clinic via Toledo, Chicago Union Station, W Jackson Blvd, after S Clinton St, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 28h 46m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There