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How to get fromCharlotte to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Charlotte to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    4h 8m
    $100–555

  2. Bus via Atlanta

    1. Take the bus from Charlotte Bus Station to Atlanta Downtownbus bus FlixBus N2470
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    15h 40m
    $126–209

  3. Train (Amtrak)

    1. Take the train from Charlotte Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    34h 30m
    $795–1,336

  4. Drive  709 mi

    1. Drive from Charlotte to St. Louiscar car 709 mi
    12h 6m
    $130–187

  5. Bus

    1. Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus bus Greyhound US0670 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    15h 46m
    $124–215

  6. Bus via Sandy Springs

    1. Take the bus from Charlotte to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    19h 12m
    $140–230

Charlotte to St. Louis by bus and subway

Calendar4Weekly Services
Duration15h 40mAverage Duration
Ticket$126Cheapest Price
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Comparing Your Travel Options

Map of how to get from Charlotte to St. Louis.ExpandLaunch map view
  • Distance: 595.4 mi
  • Duration: 4h 8m

What companies run services between Charlotte, NC, USA and St. Louis, MO, USA?

American Airlines and Southwest Airlines fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Charlotte Bus Station to St Louis Bus Station via Atlanta Downtown, Civic Center Station, Garnett Station, and Atlanta Bus Station in around 15h 40m.

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Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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Need to know: Greyhound

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