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How to get fromCharlotte to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Charlotte to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    4h 5m
    $125–705

  2. Bus

    cheapest
    1. Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus bus Greyhound US0670 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    17h 20m
    $123–240

  3. Bus via Atlanta

    1. Take the bus from Charlotte Bus Station to Atlanta Downtownbus bus FlixBus N2470
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    16h 59m
    $125–234

  4. Train (Amtrak)

    1. Take the train from Charlotte Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    34h 30m
    $497–1,002

  5. Drive 709 mi

    1. Drive from Charlotte to St. Louiscar car 709 mi
    12h 6m
    $130–187

  6. Bus via Sandy Springs

    1. Take the bus from Charlotte to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    20h 30m
    $150–345

Charlotte to St. Louis by bus and subway

Calendar5Weekly Services
Duration16h 59mAverage Duration
Ticket$125Cheapest Price
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Questions & Answers

Map of how to get from Charlotte to St. Louis.ExpandLaunch map view
  • Distance: 595.4 mi
  • Duration: 4h 5m

What companies run services between Charlotte, NC, USA and St. Louis, MO, USA?

American Airlines, Southwest Airlines, and Delta fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Charlotte Bus Station to St Louis Bus Station via Atlanta Downtown, Civic Center Station, Garnett Station, and Atlanta Bus Station in around 16h 59m.

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