There are 7 ways to get from Charlotte to Tupelo by plane, car, bus (Flixbus, Greyhound), bus, bus (Greyhound, Flixbus), or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Birmingham–Shuttlesworth International Airport, drive
best- Fly from Charlotte Douglas International Airport (CLT) to Birmingham–Shuttlesworth International Airport (BHM)plane CLT - BHM
- Drive from Birmingham-Airport-BHM to Tupelocar
5h 18m$136–742Bus
cheapest- Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus Greyhound US0670 / ...
- Take the bus from Atlanta Bus Station to Tupelobus Greyhound US0610
11h 24m$87–144Bus via Atlanta
- Take the bus from Charlotte Bus Station to Atlanta Downtownbus FlixBus N2470
- Take the bus from Atlanta Bus Station to Tupelobus Greyhound US0610
11h 18m$90–140Drive 517 mi
- Drive from Charlotte to Tupelocar 517 mi
8h 52m$95–137Fly to Huntsville International Airport-Carl T Jones Field, drive
- Fly from Charlotte Douglas International Airport (CLT) to Huntsville International Airport-Carl T Jones Field (HSV)plane CLT - HSV
- Drive from Huntsville International Airport-Carl T Jones Field (HSV) to Tupelocar
5h 31m$105–587Fly to Memphis, bus
- Fly from Charlotte Douglas International Airport (CLT) to Memphis (MEM)plane CLT - MEM
- Take the bus from Memphis Bus Station to Tupelobus
7h 21m$149–792Bus via Sandy Springs
- Take the bus from Charlotte to Atlantabus Charlotte
- Take the bus from Atlanta Bus Station to Tupelobus Greyhound US0610
14h 51m$106–164
Charlotte Douglas International Airport (CLT) to Birmingham–Shuttlesworth International Airport (BHM) flights
Comparing Your Travel Options
The cheapest way to get from Charlotte to Tupelo is to bus which costs $85 - $150 and takes 11h 24m.
The fastest way to get from Charlotte to Tupelo is to fly and drive which takes 5h 18m and costs $130 - $750.
No, there is no direct bus from Charlotte station to Tupelo. However, there are services departing from Charlotte Bus Station and arriving at Tupelo via Atlanta Bus Station. The journey, including transfers, takes approximately 11h 18m.
The distance between Charlotte and Tupelo is 496 miles. The road distance is 520 miles.
The best way to get from Charlotte to Tupelo without a car is to bus via Atlanta which takes 11h 18m and costs $90 - $140.
It takes approximately 5h 18m to get from Charlotte to Tupelo, including transfers.
Charlotte to Tupelo bus services, operated by Flixbus USA, depart from Charlotte Bus Station.
Charlotte to Tupelo bus services, operated by Flixbus USA, arrive at Atlanta Downtown station.
Tupelo is 1h behind Charlotte. It is currently 12:53 AM in Charlotte and 11:53 PM in Tupelo.
Yes, the driving distance between Charlotte to Tupelo is 520 miles. It takes approximately 8h 52m to drive from Charlotte to Tupelo.
What companies run services between Charlotte, NC, USA and Tupelo, MS, USA?
You can take a bus from Charlotte Bus Station to Tupelo via Atlanta Downtown, Civic Center Station, Garnett Station, Atlanta Bus Station, and Tupelo in around 11h 18m.
- Website
- aa.com
Flights from Charlotte Douglas International Airport to Birmingham–Shuttlesworth International Airport
- Ave. Duration
- 1h 36m
- When
- Every day
- Estimated price
- $110–700
Flights from Charlotte Douglas International Airport to Huntsville International Airport-Carl T Jones Field
- Ave. Duration
- 1h 43m
- When
- Every day
- Estimated price
- $80–550
Flights from Charlotte Douglas International Airport to Memphis
- Ave. Duration
- 1h 56m
- When
- Every day
- Estimated price
- $120–750
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Charlotte Bus Station to Atlanta Downtown
- Ave. Duration
- 4h 10m
- Frequency
- 4 times a week
- Estimated price
- $35–55
- Schedules at
- Flixbus USA
Bus from Charlotte Bus Station to Atlanta Bus Station
- Ave. Duration
- 4h 50m
- Frequency
- 3 times a day
- Estimated price
- $35–55
- Schedules at
- Flixbus USA
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Booking & Getting There
Book your Charlotte to Tupelo bus tickets online with Omio.
There are 35+ hotels available in Tupelo.

