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How to get fromCharlottesville to Louisvilleby plane, bus (Greyhound, Amtrak, Flixbus), train, bus, or car

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There are 6 ways to get from Charlottesville to Louisville by plane, bus (Greyhound, Amtrak, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Charlottesville to Louisville International Airport

    best
    1. Fly from Charlottesville (CHO) to Louisville International Airport (SDF)plane plane CHO - SDF
    5h 17m
    $134–692

  2. Drive  484.5 mi

    cheapest
    1. Drive from Charlottesville to Louisvillecar car 484.5 mi
    8h 20m
    $89–128

  3. Bus

    1. Take the bus from Charlottesville Union Station to Nashville Bus Stationbus bus Greyhound US0600
    2. Take the bus from Nashville Bus Station to Louisville Bus Stationbus bus Greyhound US0105 / ...
    16h 40m
    $112–186

  4. Train, bus

    1. Take the train from Charlottesville to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus Greyhound US0100 / ...
    18h 13m
    $172–398

  5. Train to Ronald Reagan Washington National Airport, fly to Louisville International Airport

    1. Take the train from Charlottesville to Alexandriatrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Louisville International Airport (SDF)plane plane DCA - SDF
    6h 25m
    $179–1,017

  6. Train to Ronald Reagan Washington National Airport, fly to Blue Grass Airport, drive

    1. Take the train from Charlottesville to Alexandriatrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Blue Grass Airport (LEX)plane plane DCA - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 16m
    $126–633

Charlottesville to Louisville by bus

Calendar7Weekly Buses
Duration16h 40mAverage Duration
Ticket$112Cheapest Price
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Comparing Your Travel Options

Map of how to get from Charlottesville to Louisville.ExpandLaunch map view
  • Distance: 411.7 mi
  • Duration: 5h 17m

What companies run services between Charlottesville, VA, USA and Louisville, KY, USA?

United Airlines, Delta, and American Airlines fly from Charlottesville (CHO) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Downtown Transit Station to Louisville Bus Station via W Main St at 8th St NW, Charlottesville Union Station, and Nashville Bus Station in around 16h 40m.

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