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How to get fromCheyenne to Knoxvilleby plane, bus, train, bus (Greyhound, Flixbus), car, or taxi

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There are 9 ways to get from Cheyenne to Knoxville by plane, bus, train, bus (Greyhound, Flixbus), car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Cheyenne Airport to Mcghee Tyson Airport

    best
    1. Fly from Cheyenne Airport (CYS) to Mcghee Tyson Airport (TYS)plane plane CYS - TYS
    5h 28m
    $289–1,142

  2. Fly Cheyenne Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Cheyenne Airport (CYS) to Asheville Regional Airport (AVL)plane plane CYS - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    8h 49m
    $139–562

  3. Bus, train via Ossining

    1. Take the bus from Cheyenne to Denver Union Stationbus bus
    2. Take the train from Denver to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 8h
    $706–1,387

  4. Bus

    1. Take the bus from Cheyenne to Denver Union Stationbus bus
    2. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 10h
    $531–800

  5. Drive  1,350.8 mi

    1. Drive from Cheyenne to Knoxvillecar car 1,350.8 mi
    22h 28m
    $247–357

  6. Taxi to Laramie Regional Airport, fly to Mcghee Tyson Airport

    1. Take the taxi from Cheyenne to Laramie-Airport-LARtaxi taxi
    2. Fly from Laramie Regional Airport (LAR) to Mcghee Tyson Airport (TYS)plane plane LAR - TYS
    6h 53m
    $385–1,288

  7. Bus to Denver, fly to Mcghee Tyson Airport

    1. Take the bus from Warren AFB to Denver International Airport Pickupsbus bus
    2. Fly from Denver (DEN) to Mcghee Tyson Airport (TYS)plane plane DEN - TYS
    6h 17m
    $318–1,161

  8. Bus, train

    1. Take the bus from Warren AFB to Denver International Airport Pickupsbus bus
    2. Take the train from Denver to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 9h
    $766–1,504

  9. Bus via Windsor

    1. Take the bus from Cheyenne to Harmony Transfer Centrebus bus
    2. Take the bus from Harmony Transfer Center to Union Stationbus bus
    3. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 11h
    $460–672

Cheyenne Airport (CYS) to Mcghee Tyson Airport (TYS) flights

Calendar16Weekly Planes
Duration6h 38mAverage Duration
Ticket$234Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cheyenne to Knoxville.ExpandLaunch map view
  • Distance: 1,195.4 mi
  • Duration: 5h 28m

What companies run services between Cheyenne, WY, USA and Knoxville, TN, USA?

United Airlines and Allegiant Air fly from Cheyenne Airport (CYS) to Mcghee Tyson Airport (TYS) twice daily. Alternatively, you can take a bus from Cheyenne to Knoxville via Denver Union Station, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 2d 10h.

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