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How to get fromCheyenne to Mayo Clinicby plane, bus, shuttle, car, or taxi

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There are 7 ways to get from Cheyenne to Mayo Clinic by plane, bus, shuttle, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Cheyenne Airport to Minneapolis–Saint Paul International Airport, bus

    best
    1. Fly from Cheyenne Airport (CYS) to Minneapolis–Saint Paul International Airport (MSP)plane plane CYS - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 55m
    $151–537

  2. Fly Cheyenne Airport to Rochester

    cheapest
    1. Fly from Cheyenne Airport (CYS) to Rochester (RST)plane plane CYS - RST
    8h 52m
    $87–450

  3. Bus, shuttle

    1. Take the bus from Warren AFB to Denver International Airport Pickupsbus bus
    2. Take the bus from Denver Union Station to Des Moinesbus bus
    3. Take the bus from Des Moines to Owatonnabus bus
    4. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    23h 42m
    $228–421

  4. Drive 789 mi

    1. Drive from Cheyenne to Mayo Cliniccar car 789 mi
    13h 32m
    $144–208

  5. Bus to Denver, fly to Rochester

    1. Take the bus from Warren AFB to Denver International Airport Pickupsbus bus
    2. Fly from Denver (DEN) to Rochester (RST)plane plane DEN - RST
    8h 17m
    $134–531

  6. Taxi to Laramie Regional Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the taxi from Cheyenne to Laramie-Airport-LARtaxi taxi
    2. Fly from Laramie Regional Airport (LAR) to Minneapolis–Saint Paul International Airport (MSP)plane plane LAR - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 59m
    $252–670

  7. Bus to Denver, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Warren AFB to Denver International Airport Pickupsbus bus
    2. Fly from Denver (DEN) to Minneapolis–Saint Paul International Airport (MSP)plane plane DEN - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 8m
    $215–473

Cheyenne Airport (CYS) to Minneapolis–Saint Paul International Airport (MSP) flights

Calendar19Weekly Planes
Duration5h 12mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Cheyenne to Mayo Clinic.ExpandLaunch map view
  • Distance: 719.4 mi
  • Duration: 6h 55m

What companies run services between Cheyenne, WY, USA and Mayo Clinic, MN, USA?

United Airlines, Delta, and American Airlines fly from Cheyenne Airport (CYS) to Rochester (RST) every 4 hours.

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