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How to get fromChicago Midway Airport (MDW) to Sioux Fallsby plane, subway, bus (Greyhound), train, bus, bus (Greyhound, Flixbus), bus (Flixbus), or car

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There are 7 ways to get from Chicago Midway Airport (MDW) to Sioux Falls by plane, subway, bus (Greyhound), train, bus, bus (Greyhound, Flixbus), bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago Midway International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to Sioux Falls (FSD)plane plane MDW - FSD
    4h 53m
    $77–418

  2. Subway to Chicago O'Hare International Airport, fly

    cheapest
    1. Take the subway from Midway to Clark/Lakesubway subway
    2. Fly from Chicago O'Hare International Airport (ORD) to Sioux Falls (FSD)plane plane ORD - FSD
    5h 24m
    $62–342

  3. Bus

    1. Take the bus from Chicago Bus Station to Omaha, NEbus bus Greyhound US0123S
    2. Take the bus from Omaha to Sioux Fallsbus bus Jefferson Lines 705
    17h 43m
    $136–234

  4. Train, bus

    1. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from Minneapolis to Sioux Fallsbus bus Jefferson Lines 701 / ...
    17h 54m
    $194–383

  5. Bus via Minneapolis

    1. Take the bus from Chicago Bus Station to Minneapolis Bus Stationbus bus Greyhound US0150
    2. Take the bus from Minneapolis to Sioux Fallsbus bus Jefferson Lines 701 / ...
    18h 13m
    $132–240

  6. Bus via Minneapolis #2

    1. Take the bus from Chicago Bus Station to Milwaukee Mitchell Airportbus bus
    2. Take the bus from Milwaukee Mitchell Airport to Minneapolis Bus Stationbus bus
    3. Take the bus from Minneapolis to Sioux Fallsbus bus
    20h 3m
    $140–221

  7. Drive 545.2 mi

    1. Drive from Chicago Midway Airport (MDW) to Sioux Fallscar car 545.2 mi
    10h 26m
    $100–144

Chicago Midway International Airport (MDW) to Sioux Falls (FSD) flights

Calendar27Weekly Planes
Duration5h 19mAverage Duration
Ticket$74Cheapest Price
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Questions & Answers

Map of how to get from Chicago Midway Airport (MDW) to Sioux Falls.ExpandLaunch map view
  • Distance: 478.7 mi
  • Duration: 4h 53m

What companies run services between Chicago Midway Airport (MDW), USA and Sioux Falls, SD, USA?

Delta, Southwest Airlines, and two other airlines fly from Chicago Midway International Airport (MDW) to Sioux Falls (FSD) 4 times a day. Alternatively, you can take a bus from Midway Orange Line Station to The Bus Stop via Cicero & Archer, Archer & Cicero, Archer & Green, Chicago Bus Station, Omaha, Sioux Falls, and Maple/Career NE corner in around 17h 43m.

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