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How to get fromChicago Midway Airport (MDW) to St. Louisby plane, subway, train (Amtrak), bus (Flixbus), rideshare, or car

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There are 7 ways to get from Chicago Midway Airport (MDW) to St. Louis by plane, subway, train (Amtrak), bus (Flixbus), rideshare, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago Midway International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    1h 53m
    $82–514

  2. Drive 288.2 mi

    cheapest
    1. Drive from Chicago Midway Airport (MDW) to St. Louiscar car 288.2 mi
    4h 53m
    $53–76

  3. Subway to Chicago O'Hare International Airport, fly

    1. Take the subway from Midway to Clark/Lakesubway subway
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    4h 14m
    $278–713

  4. Train (Amtrak)

    1. Take the train from Summit Amtrak to St. Louistrain train Lincoln Service / ...
    6h 6m
    $88–182

  5. Bus

    1. Take the bus from Chicago Midway Airport to Illinois Terminalbus bus Chicago / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus N2521 / ...
    6h 35m
    $74–110

  6. Train via Joliet (Amtrak)

    1. Take the train from Joliet Gateway Center to St. Louistrain train Lincoln Service / ...
    6h 55m
    $81–169

  7. Airport Transfer

    1. Take the rideshare from Chicago Midway-MDW to St. Louisrideshare rideshare 288.2 mi
    4h 53m

Chicago Midway Airport (MDW) to St. Louis by bus, foot, and train (Amtrak)

Calendar21Weekly Services
Duration6h 6mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from Chicago Midway Airport (MDW) to St. Louis.ExpandLaunch map view
  • Distance: 265.7 mi
  • Duration: 1h 53m

What companies run services between Chicago Midway Airport (MDW), USA and St. Louis, MO, USA?

Southwest Airlines flies from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL) 5 times a day. Alternatively, Amtrak operates a train from Summit Amtrak to St. Louis 3 times a day. Tickets cost $85–180 and the journey takes 4h 37m.

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