There are 7 ways to get from Chicago Union Station to Buffalo by subway, plane, bus, train (Amtrak), car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Subway to Chicago Midway International Airport, fly to Buffalo Niagara International Airport
best- Take the subway from Quincy to Midwaysubway
- Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane MDW - BUF
4h 29m$164–318Bus
cheapest- Take the bus from Chicago to Clevelandbus Chicago / ...
- Take the bus from Cleveland, OH to Buffalo, NYbus Cinncinati,OH-Buffalo / ...
11h 14m$52–139Train (Amtrak)
- Take the train from Chicago Union Station to Buffalo Depew Stationtrain Lake Shore Limited
11h 44m$140–443Drive 532.3 mi
- Drive from Chicago Union Station to Buffalocar 532.3 mi
9h 4m$98–141Fly Chicago O'Hare International Airport to Buffalo Niagara International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane ORD - BUF
4h 49m$174–308Fly Chicago Midway International Airport to Rochester, bus
- Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane MDW - ROC
- Take the bus from Rochester Bus Stop to Buffalobus
5h 58m$172–896Bus via Brook Park (Greyhound)
- Take the bus from Chicago Bus Station to Cleveland Bus Stationbus Greyhound US0164
- Take the bus from Cleveland Bus Station to Buffalobus Greyhound US0171 / ...
11h 49m$84–135
Chicago Union Station to Buffalo by foot and bus
Comparing Your Travel Options
The cheapest way to get from Chicago Union Station to Buffalo is to bus which costs $50 - $140 and takes 11h 14m.
The fastest way to get from Chicago Union Station to Buffalo is to subway and fly which takes 4h 29m and costs $160 - $320.
No, there is no direct bus from Chicago Union Station to Buffalo. However, there are services departing from Chicago and arriving at Buffalo, NY via Cleveland, OH. The journey, including transfers, takes approximately 11h 14m.
No, there is no direct train from Chicago Union Station station to Buffalo. However, there are services departing from Chicago Union Station and arriving at Buffalo via Buffalo Depew Station. The journey, including transfers, takes approximately 11h 44m.
The distance between Chicago Union Station and Buffalo is 492 miles. The road distance is 535.4 miles.
The best way to get from Chicago Union Station to Buffalo without a car is to bus which takes 11h 14m and costs $50 - $140.
It takes approximately 4h 29m to get from Chicago Union Station to Buffalo, including transfers.
Chicago Union Station to Buffalo bus services, operated by Greyhound USA, depart from Chicago Bus Station.
Chicago Union Station to Buffalo train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from Chicago Union Station to Buffalo is to bus which takes 11h 14m and costs $50 - $140. Alternatively, you can train, which costs $140 - $450 and takes 11h 44m, you could also fly, which costs $170 - $310 and takes 4h 49m.
What companies run services between Chicago Union Station, IL, USA and Buffalo, NY, USA?
You can take a vehicle from Chicago Union Station to Buffalo, NY via Chicago and Cleveland, OH in around 11h 14m. Alternatively, Amtrak operates a train from Chicago Union Station to Buffalo Depew Station twice daily. Tickets cost $130–310 and the journey takes 10h 23m.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $100–650
Flights from Chicago Midway International Airport to Rochester
- Ave. Duration
- 1h 37m
- When
- Every day
- Estimated price
- $140–850
Flights from Chicago Midway International Airport to Rochester via Baltimore
- Ave. Duration
- 4h
- When
- Tuesday and Wednesday
- Estimated price
- $190–1,000
- Phone
- +1 888-968-7282
- Website
- Chicago Transit Authority
Subway from Quincy to Midway
- Ave. Duration
- 31 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- Chicago Transit Authority
- Schedules at
- Chicago Transit Authority Schedules & Routes
- Adult
- $2–5
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Chicago to Cleveland
- Ave. Duration
- 6h 55m
- Frequency
- Twice daily
- Estimated price
- $30–80
- Website
- Barons Bus
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 3h 10m
- Frequency
- Twice daily
- Estimated price
- $18–60
- Website
- Barons Bus
Want to know more about travelling around United States
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Booking & Getting There
Chicago Union Station to Buffalo bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Buffalo is 1h ahead of Chicago Union Station. It is currently 2:44 AM in Chicago Union Station and 3:44 AM in Buffalo.
Chicago Union Station to Buffalo train services, operated by Amtrak, arrive at Buffalo Depew Station.
Yes, the driving distance between Chicago Union Station to Buffalo is 535 miles. It takes approximately 9h 4m to drive from Chicago Union Station to Buffalo.
Book your Chicago Union Station to Buffalo train tickets online with Omio.
Book your Chicago Union Station to Buffalo bus tickets online with Omio and FlixBus.
There are 256+ hotels available in Buffalo.