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How to get fromChicago Union Station to Buffaloby plane, bus, train (Amtrak), car, subway, or bus (Greyhound)

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There are 9 ways to get from Chicago Union Station to Buffalo by plane, bus, train (Amtrak), car, subway, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Buffalo Niagara International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    4h 49m
    $178–333

  2. Bus

    cheapest
    1. Take the bus from Chicago to Clevelandbus bus Bsb 26
    2. Take the bus from Cleveland to Buffalobus bus Bsb 10
    11h 14m
    $52–139

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    11h 44m
    $293–587

  4. Drive  532.3 mi

    1. Drive from Chicago Union Station to Buffalocar car 532.3 mi
    9h 4m
    $98–141

  5. Subway to Chicago Midway International Airport, fly to Buffalo Niagara International Airport

    1. Take the subway from Quincy to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    4h 34m
    $168–343

  6. Fly Chicago O'Hare International Airport to Rochester, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (ROC)plane plane ORD - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 22m
    $132–646

  7. Fly Chicago Midway International Airport to Rochester, bus

    1. Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane plane MDW - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 8m
    $172–946

  8. Fly Chicago O'Hare International Airport to Toronto Pearson International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Toronto Pearson International Airport (YYZ)plane plane ORD - YYZ
    2. Take the bus from Toronto Pearson Airport to Buffalobus bus
    8h 44m
    $406–1,028

  9. Bus via Brook Park (Greyhound)

    1. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus Greyhound US0164
    2. Take the bus from Cleveland Bus Station to Buffalobus bus Greyhound US0171 / ...
    11h 49m
    $86–142

Chicago Union Station to Buffalo by foot and bus

Calendar7Weekly Services
Duration11h 14mAverage Duration
Ticket$52Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago Union Station to Buffalo.ExpandLaunch map view
  • Distance: 500.2 mi
  • Duration: 4h 49m

What companies run services between Chicago Union Station, IL, USA and Buffalo, NY, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF) every 3 hours. Alternatively, you can take a vehicle from Chicago Union Station to Buffalo via Chicago and Cleveland in around 11h 14m.

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