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How to get fromChicago Union Station to Buffaloby subway, plane, bus, train (Amtrak), car, or bus (Greyhound)

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There are 7 ways to get from Chicago Union Station to Buffalo by subway, plane, bus, train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Chicago Midway International Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the subway from Quincy to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    4h 8m
    $104–464

  2. Bus

    cheapest
    1. Take the bus from Chicago to Clevelandbus bus Bsb 26 / ...
    2. Take the bus from Cleveland to Buffalobus bus Bsb 10 / ...
    11h 14m
    $52–191

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    11h 44m
    $173–483

  4. Drive 532.3 mi

    1. Drive from Chicago Union Station to Buffalocar car 532.3 mi
    9h 4m
    $98–141

  5. Fly Chicago O'Hare International Airport to Buffalo Niagara International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    4h 32m
    $154–404

  6. Fly Chicago Midway International Airport to Rochester, bus

    1. Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane plane MDW - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    5h 21m
    $162–799

  7. Bus via Brook Park (Greyhound)

    1. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus Greyhound US0164
    2. Take the bus from Cleveland Bus Station to Buffalobus bus Greyhound US0171 / ...
    11h 49m
    $85–163

Chicago Union Station to Buffalo by foot and bus

Calendar15Weekly Services
Duration11h 14mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

Map of how to get from Chicago Union Station to Buffalo.ExpandLaunch map view
  • Distance: 493.4 mi
  • Duration: 4h 8m

What companies run services between Chicago Union Station, IL, USA and Buffalo, NY, USA?

You can take a vehicle from Chicago Union Station to Buffalo via Chicago and Cleveland in around 11h 14m. Alternatively, Amtrak operates a train from Chicago Union Station to Buffalo Depew Station twice daily. Tickets cost $170–350 and the journey takes 10h 23m.

Airlines
Train operators
Bus operators

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