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How to get fromChicago Union Station to Jeffersonvilleby bus (Greyhound, Amtrak), train, bus, car, plane, bus (Amtrak), or subway

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There are 7 ways to get from Chicago Union Station to Jeffersonville by bus (Greyhound, Amtrak), train, bus, car, plane, bus (Amtrak), or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Indianapolis

    best
    1. Take the bus from Chicago Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    7h 32m
    $50–99

  2. Train, bus (Amtrak)

    1. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    9h 11m
    $86–176

  3. Drive 293.2 mi

    1. Drive from Chicago Union Station to Jeffersonvillecar car 293.2 mi
    5h 2m
    $54–78

  4. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Jeffersonvillecar car
    4h 51m
    $116–674

  5. Bus (Amtrak)

    1. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    8h 20m
    $51–59

  6. Subway to Chicago Midway International Airport, fly to Louisville International Airport, line 71 bus

    1. Take the subway from Quincy to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    3. Take the bus from Liberty @ 6th to Court @ Meigsbus bus
    5h 22m
    $84–561

  7. Fly Chicago O'Hare International Airport to Louisville International Airport, line 71 bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    2. Take the bus from Liberty @ 6th to Court @ Meigsbus bus
    5h 53m
    $70–431

Chicago Union Station to Jeffersonville by foot and bus

Calendar14Weekly Services
Duration7h 32mAverage Duration
Ticket$50Cheapest Price
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Questions & Answers

Map of how to get from Chicago Union Station to Jeffersonville.ExpandLaunch map view
  • Distance: 299.5 mi
  • Duration: 7h 32m

What companies run services between Chicago Union Station, IL, USA and Jeffersonville, IN, USA?

You can take a vehicle from Chicago Union Station to Court @ Spring via Chicago Bus Station, Indianapolis Union Station, Louisville, KY, and Liberty @ Roy Wilkins in around 7h 32m.

Airlines
Train operators
Bus operators

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