Rome2Rio

How to get fromChicago Union Station to Knoxvilleby plane, train, bus, bus (Flixbus), car, or subway

Find Transport to Knoxville

See all options

There are 9 ways to get from Chicago Union Station to Knoxville by plane, train, bus, bus (Flixbus), car, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    4h 2m
    $158–675

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 5m
    $84–380

  3. Train, bus

    1. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train Lake Shore Limited / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    33h 45m
    $492–883

  4. Bus

    1. Take the bus from Chicago Bus Station to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    37h 54m
    $260–381

  5. Drive 526.5 mi

    1. Drive from Chicago Union Station to Knoxvillecar car 526.5 mi
    9h 11m
    $97–139

  6. Subway to Chicago Midway International Airport, fly to Mcghee Tyson Airport

    1. Take the subway from Quincy to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    3h 34m
    $178–825

  7. Fly Chicago O'Hare International Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Chattanooga Metropolitan Airport (CHA)plane plane ORD - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 31m
    $130–683

  8. Fly Chicago Midway International Airport to Nashville, drive

    1. Fly from Chicago Midway International Airport (MDW) to Nashville (BNA)plane plane MDW - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 3m
    $102–495

  9. Train, bus via Ossining

    1. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    2. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    34h 22m
    $446–789

Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS) flights

Calendar75Weekly Planes
Duration2h 58mAverage Duration
Ticket$103Cheapest Price
See schedules

Questions & Answers

Map of how to get from Chicago Union Station to Knoxville.ExpandLaunch map view
  • Distance: 506.9 mi
  • Duration: 4h 2m

What companies run services between Chicago Union Station, IL, USA and Knoxville, TN, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a vehicle from Chicago Union Station to Knoxville Station Hall of Fame via Chicago Bus Station, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 37h 54m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

More Questions & Answers