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How to get fromChicago Union Station to La Crosseby train (Amtrak), bus (Greyhound, Flixbus), car, plane, or bus

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There are 5 ways to get from Chicago Union Station to La Crosse by train (Amtrak), bus (Greyhound, Flixbus), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    4h 59m
    $85–190

  2. Drive 281.2 mi

    cheapest
    1. Drive from Chicago Union Station to La Crossecar car 281.2 mi
    4h 40m
    $52–75

  3. Bus via Milwaukee

    1. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus Greyhound US0150 / ...
    2. Take the bus from Milwaukee to La Crossebus bus Jefferson Lines 966
    6h 29m
    $63–100

  4. Fly

    1. Fly from Chicago O'Hare International Airport (ORD) to La Crosse (LSE)plane plane ORD - LSE
    3h 35m
    $62–308

  5. Bus

    1. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to La Crossebus bus Jefferson Lines 966
    7h 10m
    $61–109

Chicago Union Station to La Crosse by train (Amtrak)

Calendar21Weekly Trains
Duration4h 59mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

Map of how to get from Chicago Union Station to La Crosse.ExpandLaunch map view
  • Distance: 279.9 mi
  • Duration: 4h 59m

What companies run services between Chicago Union Station, IL, USA and La Crosse, WI, USA?

Amtrak operates a train from Chicago Union Station to La Crosse Amtrak Station 3 times a day. Tickets cost $85–190 and the journey takes 4h 59m. Alternatively, you can take a vehicle from Chicago Union Station to La Crosse via Chicago Bus Station, Milwaukee Intermodal Station, and Milwaukee in around 6h 29m.

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