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How to get fromChicago Union Station to Louisvilleby bus (Greyhound, Amtrak), train, bus, car, subway, plane, or bus (Amtrak)

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There are 7 ways to get from Chicago Union Station to Louisville by bus (Greyhound, Amtrak), train, bus, car, subway, plane, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Indianapolis

    best
    1. Take the bus from Chicago Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    6h 39m
    $50–97

  2. Train, bus (Amtrak)

    1. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    8h 19m
    $86–174

  3. Drive 294.5 mi

    1. Drive from Chicago Union Station to Louisvillecar car 294.5 mi
    5h 4m
    $54–78

  4. Subway to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the subway from Quincy to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    4h 11m
    $84–558

  5. Bus (Amtrak)

    1. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    7h
    $50–60

  6. Fly Chicago O'Hare International Airport to Louisville International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    4h 41m
    $68–428

  7. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    4h 50m
    $116–674

Chicago Union Station to Louisville by foot and bus

Calendar14Weekly Services
Duration6h 39mAverage Duration
Ticket$50Cheapest Price
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Questions & Answers

Map of how to get from Chicago Union Station to Louisville.ExpandLaunch map view
  • Distance: 295.3 mi
  • Duration: 6h 39m

What companies run services between Chicago Union Station, IL, USA and Louisville, KY, USA?

You can take a vehicle from Chicago Union Station to Louisville, KY via Chicago Bus Station and Indianapolis Union Station in around 6h 39m. Alternatively, American Airlines and United Airlines fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF) every 3 hours.

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