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How to get fromChicago Union Station to Mayo Clinicby plane, train, bus, car, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Chicago Union Station to Mayo Clinic by plane, train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Rochester

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    4h 39m
    $44–335

  2. Train, bus via Milwaukee

    1. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    8h 17m
    $97–156

  3. Train, bus

    1. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson Lines 965
    10h 4m
    $159–308

  4. Drive 346.3 mi

    1. Drive from Chicago Union Station to Mayo Cliniccar car 346.3 mi
    5h 43m
    $64–92

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 22m
    $274–507

  6. Fly Chicago Midway International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 12m
    $130–537

  7. Bus

    1. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    9h 18m
    $76–129

  8. Bus via Chicago Bus Station

    1. Take the bus from Chicago Bus Station to Madisonbus bus FlixBus 2548 / ...
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    9h 22m
    $76–124

Chicago Union Station to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration8h 17mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

Map of how to get from Chicago Union Station to Mayo Clinic.ExpandLaunch map view
  • Distance: 295.7 mi
  • Duration: 4h 39m

What companies run services between Chicago Union Station, IL, USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from W Jackson Blvd, after S Clinton St to Mayo Clinic via 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 9h 18m.

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