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How to get fromChicago Union Station to South Carolinaby plane, train (Amtrak), car, or taxi

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There are 9 ways to get from Chicago Union Station to South Carolina by plane, train (Amtrak), car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    4h 17m
    $132–600

  2. Fly Chicago O'Hare International Airport to Charleston International Airport

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    5h 22m
    $84–417

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    28h 39m
    $429–875

  4. Drive 873 mi

    1. Drive from Chicago Union Station to Charlestoncar car 873 mi
    15h 59m
    $160–231

  5. Fly Chicago O'Hare International Airport to Charlotte Douglas International Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Charlotte Douglas International Airport (CLT)plane plane ORD - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    4h 35m
    $202–515

  6. Fly Chicago Midway International Airport to Charlotte Douglas International Airport, taxi

    1. Fly from Chicago Midway International Airport (MDW) to Charlotte Douglas International Airport (CLT)plane plane MDW - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    4h 19m
    $202–805

  7. Fly Chicago O'Hare International Airport to Asheville Regional Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    4h 53m
    $202–515

  8. Fly Chicago Midway International Airport to Charleston International Airport

    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    4h 57m
    $104–557

  9. Fly Chicago O'Hare International Airport to Columbia

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    5h 29m
    $184–957

Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) flights

Calendar98Weekly Planes
Duration3h 7mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Chicago Union Station to South Carolina.ExpandLaunch map view
  • Distance: 609 mi
  • Duration: 4h 17m

What companies run services between Chicago Union Station, IL, USA and South Carolina, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a train from Chicago Union Station to Charleston via Petersburg Amtrak Station and Charleston Amtrak Station in around 28h 39m.

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