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How to get fromChicago Union Station to St. Louisby train (Amtrak), bus (Flixbus), car, subway, plane, or train

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There are 6 ways to get from Chicago Union Station to St. Louis by train (Amtrak), bus (Flixbus), car, subway, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    4h 46m
    $90–190

  2. Bus

    cheapest
    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    6h 4m
    $50–85

  3. Drive 295.5 mi

    1. Drive from Chicago Union Station to St. Louiscar car 295.5 mi
    4h 58m
    $54–78

  4. Subway to Chicago Midway International Airport, fly

    1. Take the subway from Quincy to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    3h 42m
    $86–558

  5. Fly from Chicago O'Hare International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    3h 56m
    $276–708

  6. Train to General Mitchell International Airport, fly

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    4h 59m
    $513–921

Chicago Union Station to St. Louis by train (Amtrak)

Calendar38Weekly Trains
Duration4h 46mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

Map of how to get from Chicago Union Station to St. Louis.ExpandLaunch map view
  • Distance: 280.7 mi
  • Duration: 4h 46m

What companies run services between Chicago Union Station, IL, USA and St. Louis, MO, USA?

Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $90–190 and the journey takes 4h 46m. Alternatively, FlixBus-us operates a bus from Chicago Bus Station to St Louis Bus Station 3 times a day, and the journey takes 5h 55m. Flixbus USA also services this route twice daily.

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