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How to get fromChicago to Buffalo Central Terminalby subway, plane, bus, train (Amtrak), car, or bus (Greyhound)

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There are 8 ways to get from Chicago to Buffalo Central Terminal by subway, plane, bus, train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Chicago Midway International Airport, fly to Buffalo Niagara International Airport, line 1 bus

    best
    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    3. Take the bus from Ellicott Street & MTC Static to William Street & Lewis Streetbus bus
    5h 3m
    $106–466

  2. Bus

    cheapest
    1. Take the bus from Chicago to Clevelandbus bus Chicago
    2. Take the bus from Cleveland, OH to Buffalo, NYbus bus Cinncinati,OH-Buffalo
    12h
    $54–141

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    10h 33m
    $195–373

  4. Drive 532.5 mi

    1. Drive from Chicago to Buffalo Central Terminalcar car 532.5 mi
    9h 6m
    $98–141

  5. Fly Chicago O'Hare International Airport to Buffalo Niagara International Airport, line 1 bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    2. Take the bus from Ellicott Street & MTC Static to William Street & Lewis Streetbus bus
    5h 29m
    $156–406

  6. Fly Chicago Midway International Airport to Rochester, bus

    1. Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane plane MDW - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 49m
    $164–801

  7. Fly Chicago O'Hare International Airport to Rochester, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (ROC)plane plane ORD - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 15m
    $134–651

  8. Bus via Brook Park (Greyhound)

    1. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus Greyhound US0164
    2. Take the bus from Cleveland Bus Station to Buffalobus bus Greyhound US0171 / ...
    12h 35m
    $87–164

Chicago to Buffalo Central Terminal by bus and foot

Calendar7Weekly Services
Duration12hAverage Duration
Ticket$54Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Buffalo Central Terminal.ExpandLaunch map view
  • Distance: 498.7 mi
  • Duration: 5h 3m

What companies run services between Chicago, IL, USA and Buffalo Central Terminal, NY, USA?

Amtrak operates a train from Chicago Union Station to Buffalo Depew Station twice daily. Tickets cost $170–350 and the journey takes 10h 23m. Alternatively, you can take a bus from Chicago to Buffalo Central Terminal via Cleveland, OH, Ellicott Street & MTC Static, and Broadway & Warren Avenue in around 12h.

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