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How to get fromChicago to Buffalo Cityby train (Amtrak), bus (Greyhound, Flixbus), car, plane, taxi, or bus

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There are 7 ways to get from Chicago to Buffalo City by train (Amtrak), bus (Greyhound, Flixbus), car, plane, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to Winonatrain train Empire Builder / ...
    5h 56m
    $168–286

  2. Fly to Chippewa Valley Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Chippewa Valley Regional Airport (EAU)plane plane ORD - EAU
    2. Drive from Eau-Claire-Airport-EAU to Buffalo Citycar car
    4h 37m
    $52–311

  3. Bus via Milwaukee

    1. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus Greyhound US0150 / ...
    2. Take the bus from Milwaukee to Winona St. Universitybus bus Jefferson Lines 966
    7h 51m
    $138–195

  4. Drive 323.5 mi

    1. Drive from Chicago to Buffalo Citycar car 323.5 mi
    5h 25m
    $59–86

  5. Fly to La Crosse, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to La Crosse (LSE)plane plane ORD - LSE
    2. Take the taxi from La-Crosse-Airport-LSE to Buffalo Citytaxi taxi
    4h 2m
    $202–485

  6. Bus

    1. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Winona St. Universitybus bus Jefferson Lines 966
    8h 41m
    $131–204

  7. Fly to Rochester, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    2. Drive from Rochester-Airport-RST to Buffalo Citycar car
    4h 37m
    $54–313

Chicago O'Hare International Airport (ORD) to La Crosse (LSE) flights

Calendar28Weekly Planes
Duration1h 22mAverage Duration
Ticket$41Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Buffalo City.ExpandLaunch map view
  • Distance: 325.4 mi
  • Duration: 5h 56m

What companies run services between Chicago, IL, USA and Buffalo City, WI, USA?

Amtrak operates a train from Chicago Union Station to Winona 3 times a day. Tickets cost $95–210 and the journey takes 5h 29m. Alternatively, you can take a bus from Chicago Bus Station to Buffalo City via Milwaukee Intermodal Station, Milwaukee, and Winona St. University in around 7h 51m.

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