There are 5 ways to get from Chicago to Buffalo Depew Station by plane, train (Amtrak), bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Chicago Midway International Airport
best- Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane MDW - BUF
3h 5m$114–449Bus
cheapest- Take the bus from Chicago Bus Station to Cleveland Bus Stationbus Greyhound US0164
- Take the bus from Cleveland, OH to Buffalo, NYbus Cinncinati,OH-Buffalo
13h 33m$56–143Train (Amtrak)
- Take the train from Chicago Union Station to Buffalo Depew Stationtrain Lake Shore Limited
10h 23m$170–350Drive 534.6 mi
- Drive from Chicago to Buffalo Depew Stationcar 534.6 mi
9h 6m$98–141Fly from Chicago O'Hare International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane ORD - BUF
3h 31m$164–389
Chicago to Buffalo Depew Station by train (Amtrak)
Questions & Answers
The cheapest way to get from Chicago to Buffalo Depew Station is to bus which costs $55 - $150 and takes 13h 33m.
The fastest way to get from Chicago to Buffalo Depew Station is to fly which takes 3h 5m and costs $110 - $450.
No, there is no direct bus from Chicago station to Buffalo Depew Station. However, there are services departing from Chicago Bus Station and arriving at Walden Avenue & 2929 Walden Avenue via Cleveland, OH, Ellicott Street & MTC Static and Walden Avenue & Thruway Transit Center. The journey, including transfers, takes approximately 13h 33m.
Yes, there is a direct train departing from Chicago Union Station station and arriving at Buffalo Depew Station station. Services depart twice daily, and operate every day. The journey takes approximately 10h 23m.
The distance between Chicago and Buffalo Depew Station is 483 miles. The road distance is 537.7 miles.
The best way to get from Chicago to Buffalo Depew Station without a car is to train which takes 10h 23m and costs $170 - $350.
It takes approximately 3h 5m to get from Chicago to Buffalo Depew Station, including transfers.
Chicago to Buffalo Depew Station bus services, operated by Greyhound-us, depart from Chicago Bus Station.
Chicago to Buffalo Depew Station train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from Chicago to Buffalo Depew Station is to fly which takes 3h 5m and costs $110 - $450. Alternatively, you can train, which costs $170 - $350 and takes 10h 23m, you could also bus, which costs $55 - $150 and takes 13h 33m.
What companies run services between Chicago, IL, USA and Buffalo Depew Station, NY, USA?
Southwest Airlines and Delta fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF) 4 times a day. Alternatively, Amtrak operates a train from Chicago Union Station to Buffalo Depew Station twice daily. Tickets cost $170–350 and the journey takes 10h 23m.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- $120–700
- Website
- united.com
Flights from Chicago O'Hare International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 47m
- When
- Every day
- Estimated price
- $95–550
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 48m
- When
- Every day
- Estimated price
- $95–550
- Website
- delta.com
Flights from Chicago Midway International Airport to Buffalo Niagara International Airport via Detroit
- Ave. Duration
- 3h 27m
- When
- Every day
- Estimated price
- $120–700
Flights from Chicago O'Hare International Airport to Buffalo Niagara International Airport via Detroit
- Ave. Duration
- 3h 31m
- When
- Every day
- Estimated price
- $95–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Buffalo Depew Station
- Ave. Duration
- 10h 23m
- Frequency
- Twice daily
- Estimated price
- $170–350
- Website
- https://www.amtrak.com/home.html
- Website
- greyhound.com
Bus from Chicago Bus Station to Cleveland Bus Station
- Ave. Duration
- 7h 10m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Schedules at
- greyhound.com
- Phone
- +1 888-378-3823
- [email protected]
- Website
- baronsbus.com
Bus from Chicago Bus Station to Cleveland Bus Station
- Ave. Duration
- 6h 55m
- Frequency
- Once daily
- Estimated price
- $30–80
- Website
- https://baronsbus.com
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $18–60
- Website
- https://baronsbus.com
- Website
- example.com
Bus from Chicago Bus Station to Cleveland Bus Station
- Ave. Duration
- 6h 55m
- Frequency
- Once daily
- Schedules at
- example.com
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Schedules at
- example.com
Want to know more about travelling around United States
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More Questions & Answers
Chicago to Buffalo Depew Station bus services, operated by Greyhound-us, arrive at Cleveland Bus Station.
Buffalo Depew Station is 1h ahead of Chicago. It is currently 2:27 AM in Chicago and 3:27 AM in Buffalo Depew Station.
Chicago to Buffalo Depew Station train services, operated by Amtrak, arrive at Buffalo Depew Station.
Yes, the driving distance between Chicago to Buffalo Depew Station is 538 miles. It takes approximately 9h 6m to drive from Chicago to Buffalo Depew Station.
Book your Chicago to Buffalo Depew Station train tickets online with Omio.
There are 241+ hotels available in Buffalo Depew Station.