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How to get fromChicago to Buffalo, NYby plane, bus, train (Amtrak), car, or bus (Greyhound)

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There are 7 ways to get from Chicago to Buffalo, NY by plane, bus, train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Buffalo Niagara International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    4h 14m
    $168–343

  2. Bus

    cheapest
    1. Take the bus from Chicago to Clevelandbus bus Chicago
    2. Take the bus from Cleveland, OH to Buffalo, NYbus bus Cinncinati,OH-Buffalo
    11h 5m
    $52–139

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    12h 15m
    $151–322

  4. Drive 531.2 mi

    1. Drive from Chicago to Buffalo, NYcar car 531.2 mi
    9h 5m
    $97–140

  5. Fly Chicago O'Hare International Airport to Buffalo Niagara International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    4h 40m
    $178–333

  6. Fly Chicago Midway International Airport to Rochester, bus

    1. Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane plane MDW - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    5h 48m
    $170–847

  7. Bus via Brook Park (Greyhound)

    1. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus Greyhound US0164
    2. Take the bus from Cleveland Bus Station to Buffalobus bus Greyhound US0171 / ...
    11h 40m
    $77–146

Chicago to Buffalo, NY by bus

Calendar7Weekly Buses
Duration11h 5mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Buffalo, NY.ExpandLaunch map view
  • Distance: 487.3 mi
  • Duration: 4h 14m

What companies run services between Chicago, IL, USA and Buffalo, NY, USA?

Southwest Airlines flies from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF) 3 times a day. Alternatively, you can take a bus from Chicago to Buffalo, NY via Cleveland, OH in around 11h 5m.

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