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How to get fromChicago to Cairoby train, taxi, bus, car, or plane

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There are 8 ways to get from Chicago to Cairo by train, taxi, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, taxi via Carbondale

    best
    1. Take the train from Chicago Union Station to Carbondaletrain train Saluki / ...
    2. Take the taxi from Carbondale to Cairotaxi taxi
    6h 31m
    $221–352

  2. Drive 371.7 mi

    cheapest
    1. Drive from Chicago to Cairocar car 371.7 mi
    6h 8m
    $68–98

  3. Bus, taxi

    1. Take the bus from Chicago to Anna - Shellbus bus Chicago
    2. Take the taxi from Anna - Shell to Cairotaxi taxi
    7h 22m
    $146–278

  4. Fly to Williamson County Regional Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane plane ORD - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cairotaxi taxi
    4h 10m
    $208–385

  5. Train, taxi (Amtrak)

    1. Take the train from Chicago Union Station to Fulton Amtrak Stationtrain train City of New Orleans
    2. Take the taxi from Fulton Amtrak Station to Cairotaxi taxi
    8h 44m
    $242–415

  6. Bus, taxi via St. Louis

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Cairotaxi taxi
    9h 52m
    $149–213

  7. Fly to Barkley Regional Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane plane ORD - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cairotaxi taxi
    3h 55m
    $118–385

  8. Fly to Cape Girardeau Municipal Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)plane plane ORD - CGI
    2. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Cairotaxi taxi
    4h 24m
    $188–325

Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA) flights

Calendar19Weekly Planes
Duration1h 31mAverage Duration
Ticket$49Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Cairo.ExpandLaunch map view
  • Distance: 361.9 mi
  • Duration: 6h 31m

What companies run services between Chicago, IL, USA and Cairo, IL, USA?

There is no direct connection from Chicago to Cairo. However, you can take the train to Carbondale then take the taxi to Cairo. Alternatively, you can take the subway to 35th/Archer, walk to 35th/Archer Orange Line Station, take the line 35 bus to California & 35th Street, walk to Chicago, take the bus to Anna - Shell, then take the taxi to Cairo.

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