Rome2Rio

How to get fromChicago to Cape Girardeauby train, taxi, bus, car, plane, or bus (Flixbus, Greyhound)

Find Transport to Cape Girardeau

See all options

There are 9 ways to get from Chicago to Cape Girardeau by train, taxi, bus, car, plane, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, taxi

    best
    1. Take the train from Chicago Union Station to Carbondaletrain train Saluki / ...
    2. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    6h 30m
    $180–305

  2. Drive  371.6 mi

    cheapest
    1. Drive from Chicago to Cape Girardeaucar car 371.6 mi
    6h 17m
    $68–98

  3. Bus, taxi

    1. Take the bus from Chicago to Anna - Shellbus bus Chicago
    2. Take the taxi from Anna - Shell to Cape Girardeautaxi taxi
    7h 40m
    $146–188

  4. Fly Chicago O'Hare International Airport to Williamson County Regional Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane plane ORD - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    4h 17m
    $212–375

  5. Train, bus

    1. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus Greyhound US1173
    7h 55m
    $97–197

  6. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus Greyhound US1173
    9h 4m
    $71–107

  7. Fly Chicago O'Hare International Airport to Barkley Regional Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane plane ORD - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    4h 36m
    $182–465

  8. Fly Chicago Midway International Airport to Lambert–St. Louis International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    6h 36m
    $104–595

  9. Fly Chicago O'Hare International Airport to Lambert–St. Louis International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    6h 57m
    $350–745

Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA) flights

Calendar14Weekly Planes
Duration1h 22mAverage Duration
Ticket$45Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Chicago to Cape Girardeau.ExpandLaunch map view
  • Distance: 354.9 mi
  • Duration: 6h 30m

What companies run services between Chicago, IL, USA and Cape Girardeau, MO, USA?

You can take a bus from Chicago Bus Station to Cape Girardeau via St Louis Bus Station and Cape Girardeau in around 9h 4m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There