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How to get fromChicago to Carlisleby plane, car, train (Amtrak), bus (Flixbus), bus, or bus (Greyhound)

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There are 7 ways to get from Chicago to Carlisle by plane, car, train (Amtrak), bus (Flixbus), bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Lancaster, drive

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Lancaster (LNS)plane plane ORD - LNS
    2. Drive from Lancaster-Airport-LNS to Carlislecar car
    4h 57m
    $78–380

  2. Fly to Harrisburg International Airport, bus

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Harrisburg International Airport (MDT)plane plane ORD - MDT
    2. Take the bus from Market Square Transfer Center to Hanover St & High Stbus bus
    6h 16m
    $70–369

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train Floridian
    2. Take the train from Pittsburgh Amtrak Station to Harrisburgtrain train Pennsylvanian
    17h 40m
    $229–475

  4. Bus (Flixbus)

    1. Take the bus from Chicago Bus Station to Harrisburg Bus Stationbus bus FlixBus N2640 / ...
    17h 46m
    $125–205

  5. Drive 642.6 mi

    1. Drive from Chicago to Carlislecar car 642.6 mi
    10h 32m
    $118–170

  6. Fly to Penn State University Park Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Penn State University Park Airport (SCE)plane plane ORD - SCE
    2. Take the bus from State College Regional Airport to Harrisburg Bus Stationbus bus
    8h 15m
    $78–372

  7. Bus via Baltimore (Greyhound)

    1. Take the bus from Chicago Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0164
    2. Take the bus from Baltimore Downtown Bus Station to Harrisburg Bus Stationbus bus Greyhound US0430
    22h 21m
    $126–239

Chicago to Carlisle by train, foot, and bus (Amtrak)

Calendar7Weekly Services
Duration17h 40mAverage Duration
Ticket$229Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Carlisle.ExpandLaunch map view
  • Distance: 690.5 mi
  • Duration: 4h 57m

What companies run services between Chicago, IL, USA and Carlisle, PA, USA?

You can take a train from Chicago Union Station to N Hanover St & Louther St WB via Pittsburgh Amtrak Station, Harrisburg, and Market Square Transfer Center in around 17h 40m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to Harrisburg Bus Station once daily. Tickets cost $120–210 and the journey takes 15h 55m.

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