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How to get fromChicago to Charlestonby plane, taxi, train, bus, or car

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There are 8 ways to get from Chicago to Charleston by plane, taxi, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Cape Girardeau Municipal Airport, taxi

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)plane plane ORD - CGI
    2. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Charlestontaxi taxi
    4h 9m
    $168–315

  2. Drive 380.7 mi

    cheapest
    1. Drive from Chicago to Charlestoncar car 380.7 mi
    6h 14m
    $70–101

  3. Train, bus, taxi

    1. Take the train from Chicago Union Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Charlestontaxi taxi
    8h 37m
    $182–314

  4. Bus

    1. Take the bus from Tornado Bus Co - Chicago to Flying J - Matthewsbus bus Milwaukee
    9h 20m
    $136–268

  5. Fly Chicago O'Hare International Airport to Barkley Regional Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane plane ORD - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Charlestontaxi taxi
    4h 10m
    $138–425

  6. Fly Chicago O'Hare International Airport to Williamson County Regional Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane plane ORD - MWA
    2. Take the bus from Marathon Gas Station - Marion to Flying J - Matthewsbus bus
    6h 3m
    $186–446

  7. Fly Chicago Midway International Airport to Lambert–St. Louis International Airport, bus, taxi

    1. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Charlestontaxi taxi
    7h 19m
    $172–688

  8. Train, drive (Amtrak)

    1. Take the train from Chicago Union Station to Fulton Amtrak Stationtrain train City of New Orleans
    2. Drive from Fulton Amtrak Station to Charlestoncar car
    8h 59m
    $139–281

Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI) flights

Calendar7Weekly Planes
Duration1h 40mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Charleston.ExpandLaunch map view
  • Distance: 388.6 mi
  • Duration: 4h 9m

What companies run services between Chicago, IL, USA and Charleston, MO, USA?

Tornado Bus Company operates a bus from Tornado Bus Co - Chicago to Flying J - Matthews once daily. Tickets cost $75–190 and the journey takes 7h 24m.

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