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How to get fromChicago to Charlestonby subway, plane, bus (Greyhound, Flixbus), train (Amtrak), or car

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There are 6 ways to get from Chicago to Charleston by subway, plane, bus (Greyhound, Flixbus), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Chicago Midway International Airport, fly to Charleston International Airport

    best
    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    5h 13m
    $104–557

  2. Fly Chicago O'Hare International Airport to Charleston International Airport

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    5h 40m
    $90–427

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus FlixBus 2512 / ...
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    28h 34m
    $189–360

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    28h 39m
    $435–871

  5. Drive 872.2 mi

    1. Drive from Chicago to Charlestoncar car 872.2 mi
    15h 59m
    $160–230

  6. Fly Chicago O'Hare International Airport to Hilton Head Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Hilton Head Airport (HHH)plane plane ORD - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    6h 24m
    $100–422

Chicago to Charleston by bus

Calendar7Weekly Buses
Duration28h 34mAverage Duration
Ticket$189Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Charleston.ExpandLaunch map view
  • Distance: 771.4 mi
  • Duration: 5h 13m

What companies run services between Chicago, IL, USA and Charleston, SC, USA?

You can take a bus from Chicago Bus Station to Transit Mall via Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 28h 34m. Alternatively, you can take a train from Chicago Union Station to Charleston via Petersburg Amtrak Station and Charleston Amtrak Station in around 28h 39m.

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