Rome2Rio

How to get fromChicago to Cleveland Clinicby subway, plane, train (Amtrak), bus (Amtrak), car, or bus (Greyhound)

Find Transport to Cleveland Clinic

See all options

There are 6 ways to get from Chicago to Cleveland Clinic by subway, plane, train (Amtrak), bus (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Chicago Midway International Airport, fly

    best
    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Cleveland-Hopkins International Airport (CLE)plane plane MDW - CLE
    3h 53m
    $90–558

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus Greyhound US0164
    8h 21m
    $58–105

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Cleveland Amtraktrain train Floridian / ...
    7h 6m
    $115–227

  4. Bus via Toledo

    1. Take the bus from Chicago Union Station to Toledobus bus Amtrak Thruway Connecting Service
    2. Take the bus from Toledo to Clevelandbus bus Chicago
    7h 32m
    $102–172

  5. Drive 346.3 mi

    1. Drive from Chicago to Cleveland Cliniccar car 346.3 mi
    5h 48m
    $64–92

  6. Fly from Chicago O'Hare International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Cleveland-Hopkins International Airport (CLE)plane plane ORD - CLE
    4h 23m
    $376–808

Chicago to Cleveland Clinic by bus and foot

Calendar2Weekly Services
Duration7h 32mAverage Duration
Ticket$102Cheapest Price
See schedules

Questions & Answers

Map of how to get from Chicago to Cleveland Clinic.ExpandLaunch map view
  • Distance: 335.1 mi
  • Duration: 3h 53m

What companies run services between Chicago, IL, USA and Cleveland Clinic, OH, USA?

Amtrak operates a train from Chicago Union Station to Cleveland Amtrak 3 times a day. Tickets cost $110–230 and the journey takes 6h 5m. Alternatively, you can take a bus from Chicago Union Station to Cleveland Clinic via Toledo, Cleveland, Chester Av & E 15Th St, and E 105Th St & Carnegie Av in around 7h 32m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers