There are 7 ways to get from Chicago to De Soto by train (Amtrak), bus, car, plane, bus (Flixbus, Amtrak), or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Chicago Union Station to Carbondaletrain Saluki / ...
5h 39m$115–223Drive 324.4 mi
cheapest- Drive from Chicago to De Sotocar 324.4 mi
5h 33m$60–86Bus
- Take the bus from Chicago to Marathon Gas Station - Marionbus Chicago / ...
7h 11m$112–238Fly to Williamson County Regional Airport
- Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane ORD - MWA
3h 33m$122–280Bus via St. Louis
- Take the bus from Chicago Bus Station to St Louis Bus Stationbus FlixBus 2510 / ...
- Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus FlixBus N2521
8h 54m$82–148Fly to Barkley Regional Airport, drive
- Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane ORD - PAH
- Drive from Barkley Regional Airport (PAH) to De Sotocar
4h 42m$60–335Fly to Cape Girardeau Municipal Airport, taxi
- Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)plane ORD - CGI
- Take the taxi from Cape Girardeau Municipal Airport (CGI) to De Sototaxi
4h 44m$228–385
Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA) flights
Questions & Answers
The cheapest way to get from Chicago to De Soto is to drive which costs $55 - $90 and takes 5h 33m.
The fastest way to get from Chicago to De Soto is to fly which takes 3h 33m and costs $120 - $280.
No, there is no direct bus from Chicago to De Soto station. However, there are services departing from State & Harrison/Ida B Wells Drive and arriving at Marathon Gas Station - Marion via 35th/Archer Orange Line Station and Chicago. The journey, including transfers, takes approximately 7h 11m.
No, there is no direct train from Chicago station to De Soto. However, there are services departing from Chicago Union Station and arriving at Carbondale via . The journey, including transfers, takes approximately 5h 39m.
The distance between Chicago and De Soto is 317 miles. The road distance is 326.3 miles.
The best way to get from Chicago to De Soto without a car is to train which takes 5h 39m and costs $110 - $230.
It takes approximately 5h 39m to get from Chicago to De Soto, including transfers.
Chicago to De Soto bus services, operated by Tornado Bus Company, depart from Chicago station.
Chicago to De Soto train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from Chicago to De Soto is to train which takes 5h 39m and costs $110 - $230. Alternatively, you can bus, which costs $110 - $240 and takes 7h 11m, you could also fly, which costs $120 - $280 and takes 3h 33m.
What companies run services between Chicago, IL, USA and De Soto, IL, USA?
Amtrak operates a train from Chicago Union Station to Carbondale 3 times a day. Tickets cost $95–210 and the journey takes 5h 30m. Alternatively, Tornado Bus Company operates a bus from Chicago to Marathon Gas Station - Marion once daily. Tickets cost $65–180 and the journey takes 5h 5m.
- Website
- contouraviation.com
Flights from Chicago O'Hare International Airport to Williamson County Regional Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $80–220
Flights from Chicago O'Hare International Airport to Cape Girardeau Municipal Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $95–220
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Williamson County Regional Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- $45–290
- Website
- united.com
Flights from Chicago O'Hare International Airport to Barkley Regional Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- $45–310
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Chicago Union Station to Carbondale
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $95–210
- Website
- Amtrak
- Phone
- +1 888 358 6762
- [email protected]
- Website
- Tornado Bus Company
Bus from Chicago to Marathon Gas Station - Marion
- Ave. Duration
- 5h 5m
- Frequency
- Once daily
- Estimated price
- $65–180
- Schedules at
- Tornado Bus Company
- Adults 11-59
- $65–180
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 55m
- Frequency
- 4 times a day
- Estimated price
- $50–85
- Schedules at
- Flixbus USA
Bus from St Louis Bus Station to Carbondale Intermodal Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $15–26
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from St Louis Bus Station to Carbondale Intermodal Station
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–45
- Website
- Amtrak
Want to know more about travelling around United States
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More Questions & Answers
Chicago to De Soto bus services, operated by Tornado Bus Company, arrive at Marathon Gas Station - Marion.
Chicago to De Soto train services, operated by Amtrak, arrive at Carbondale station.
Yes, the driving distance between Chicago to De Soto is 326 miles. It takes approximately 5h 33m to drive from Chicago to De Soto.
There are 30+ hotels available in De Soto.