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How to get fromChicago to De Sotoby train, taxi, bus, car, or plane

Find Transport to De Soto

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There are 7 ways to get from Chicago to De Soto by train, taxi, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, taxi

    best
    1. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    2. Take the taxi from La Crosse Amtrak Station to De Sototaxi taxi
    5h 42m
    $160–269

  2. Drive 240.6 mi

    cheapest
    1. Drive from Chicago to De Sotocar car 240.6 mi
    5h 23m
    $44–64

  3. Bus, taxi via Milwaukee

    1. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    2. Take the bus from Milwaukee to La Crossebus bus
    3. Take the taxi from La Crosse to De Sototaxi taxi
    6h 59m
    $128–180

  4. Fly to La Crosse, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to La Crosse (LSE)plane plane ORD - LSE
    2. Take the taxi from La-Crosse-Airport-LSE to De Sototaxi taxi
    3h 57m
    $122–385

  5. Bus, taxi

    1. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    2. Take the bus from Madison to La Crossebus bus
    3. Take the taxi from La Crosse to De Sototaxi taxi
    7h 49m
    $126–189

  6. Fly to The Eastern Iowa Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to The Eastern Iowa Airport (CID)plane plane ORD - CID
    2. Drive from Cedar-Rapids-Airport-CID to De Sotocar car
    5h 48m
    $66–325

  7. Fly to Waterloo Municipal Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Waterloo Municipal Airport (ALO)plane plane ORD - ALO
    2. Drive from Waterloo Municipal Airport (ALO) to De Sotocar car
    5h 46m
    $64–320

Chicago O'Hare International Airport (ORD) to La Crosse (LSE) flights

Calendar28Weekly Planes
Duration1h 22mAverage Duration
Ticket$41Cheapest Price
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Questions & Answers

Map of how to get from Chicago to De Soto.ExpandLaunch map view
  • Distance: 310.1 mi
  • Duration: 5h 42m

What companies run services between Chicago, IL, USA and De Soto, WI, USA?

There is no direct connection from Chicago to De Soto. However, you can take the train to La Crosse Amtrak Station then take the taxi to De Soto. Alternatively, you can take the bus to Milwaukee Intermodal Station, walk to Milwaukee, take the bus to La Crosse, then take the taxi to De Soto.

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