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How to get fromChicago to Florenceby plane, car, bus (Greyhound, Flixbus), or bus

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There are 9 ways to get from Chicago to Florence by plane, car, bus (Greyhound, Flixbus), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Birmingham–Shuttlesworth International Airport, drive

    best
    1. Fly from Chicago Midway International Airport (MDW) to Birmingham–Shuttlesworth International Airport (BHM)plane plane MDW - BHM
    2. Drive from Birmingham-Airport-BHM to Florencecar car
    5h 23m
    $154–790

  2. Drive 530.9 mi

    cheapest
    1. Drive from Chicago to Florencecar car 530.9 mi
    11h 24m
    $97–140

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus FlixBus 2512 / ...
    2. Take the bus from Atlanta Bus Station to Florencebus bus Greyhound US0622s
    23h
    $172–327

  4. Fly Chicago O'Hare International Airport to Birmingham–Shuttlesworth International Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Birmingham–Shuttlesworth International Airport (BHM)plane plane ORD - BHM
    2. Drive from Birmingham-Airport-BHM to Florencecar car
    5h 56m
    $134–640

  5. Fly Chicago Midway International Airport to Nashville, drive

    1. Fly from Chicago Midway International Airport (MDW) to Nashville (BNA)plane plane MDW - BNA
    2. Drive from Nashville-Airport-BNA to Florencecar car
    5h 44m
    $98–480

  6. Fly Chicago O'Hare International Airport to Nashville, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Nashville (BNA)plane plane ORD - BNA
    2. Drive from Nashville-Airport-BNA to Florencecar car
    6h 7m
    $124–340

  7. Fly Chicago Midway International Airport to Memphis, drive

    1. Fly from Chicago Midway International Airport (MDW) to Memphis (MEM)plane plane MDW - MEM
    2. Drive from Memphis-Airport-MEM to Florencecar car
    5h 52m
    $158–795

  8. Fly Chicago O'Hare International Airport to Huntsville International Airport-Carl T Jones Field, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Huntsville International Airport-Carl T Jones Field (HSV)plane plane ORD - HSV
    2. Take the bus from Huntsville, AL to Florencebus bus
    6h 42m
    $146–512

  9. Fly Chicago O'Hare International Airport to Mc Kellar-Sipes Regional Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Mc Kellar-Sipes Regional Airport (MKL)plane plane ORD - MKL
    2. Drive from Mc Kellar-Sipes Regional Airport (MKL) to Florencecar car
    6h 6m
    $116–273

Chicago Midway International Airport (MDW) to Birmingham–Shuttlesworth International Airport (BHM) flights

Calendar35Weekly Planes
Duration3h 10mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Florence.ExpandLaunch map view
  • Distance: 699.8 mi
  • Duration: 5h 23m

What companies run services between Chicago, IL, USA and Florence, AL, USA?

You can take a bus from Chicago Bus Station to Florence via Atlanta Bus Station and Florence in around 23h.

Airlines
Bus operators

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