Rome2Rio

How to get fromChicago to Florenceby plane, bus, bus (Greyhound), train (Amtrak), car, train, or bus (Greyhound, Flixbus)

Find Transport to Florence

See all options

There are 10 ways to get from Chicago to Florence by plane, bus, bus (Greyhound), train (Amtrak), car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Myrtle Beach, bus

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Myrtle Beach (MYR)plane plane ORD - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 49m
    $80–338

  2. Bus via Columbus

    1. Take the bus from Chicago to Columbusbus bus
    2. Take the bus from Columbus to Charlottebus bus
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Florence Bus Stationbus bus
    23h 25m
    $100–211

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Selma Stationtrain train
    3. Take the train from Selma Station to Florence Stationtrain train
    29h 14m
    $675–1,050

  4. Drive  830.5 mi

    1. Drive from Chicago to Florencecar car 830.5 mi
    15h 49m
    $147–212

  5. Fly Chicago Midway International Airport to Charleston International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    8h 24m
    $166–744

  6. Fly Chicago O'Hare International Airport to Charleston International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    8h 45m
    $556–944

  7. Fly Chicago O'Hare International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Charlotte Douglas International Airport (CLT)plane plane ORD - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    9h 10m
    $114–537

  8. Fly Chicago Midway International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Charlotte Douglas International Airport (CLT)plane plane MDW - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    8h 52m
    $170–847

  9. Fly Chicago O'Hare International Airport to Columbia, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    2. Take the bus from Columbia, SC to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    9h 47m
    $98–383

  10. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus Greyhound US0641S / ...
    23h 25m
    $171–281

Chicago to Florence by bus

Calendar7Weekly Buses
Duration23h 25mAverage Duration
Ticket$100Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Chicago to Florence.ExpandLaunch map view
  • Distance: 841.6 mi
  • Duration: 6h 49m

What companies run services between Chicago, IL, USA and Florence, SC, USA?

You can take a bus from Chicago to Florence Bus Station via Columbus, Charlotte Bus Station, and Camden in around 23h 25m. Alternatively, you can take a train from Chicago Union Station to Florence Station via Raleigh Union Station and Selma Station in around 29h 14m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There