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How to get fromChicago to Florenceby plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, or train

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There are 10 ways to get from Chicago to Florence by plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Myrtle Beach, bus

    best
    1. Fly from Chicago Midway International Airport (MDW) to Myrtle Beach (MYR)plane plane MDW - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 21m
    $104–486

  2. Fly Chicago O'Hare International Airport to Myrtle Beach, bus

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Myrtle Beach (MYR)plane plane ORD - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 49m
    $84–366

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus Greyhound US0641S / ...
    23h 25m
    $153–252

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Florence Stationtrain train Palmetto / ...
    27h 9m
    $286–682

  5. Drive  830.4 mi

    1. Drive from Chicago to Florencecar car 830.4 mi
    15h 48m
    $152–219

  6. Fly Chicago Midway International Airport to Charleston International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    8h 24m
    $140–664

  7. Fly Chicago O'Hare International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Charlotte Douglas International Airport (CLT)plane plane ORD - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    9h 7m
    $146–433

  8. Fly Chicago Midway International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Charlotte Douglas International Airport (CLT)plane plane MDW - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    8h 43m
    $136–743

  9. Fly Chicago O'Hare International Airport to Columbia, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    2. Take the bus from Columbia, SC to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    9h 52m
    $102–401

  10. Train, bus

    1. Take the train from Chicago Union Station to Raleigh Union Stationtrain train Floridian
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    28h 38m
    $289–660

Chicago to Florence by bus

Calendar14Weekly Buses
Duration23h 25mAverage Duration
Ticket$153Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Florence.ExpandLaunch map view
  • Distance: 819.6 mi
  • Duration: 6h 21m

What companies run services between Chicago, IL, USA and Florence, SC, USA?

You can take a bus from Chicago Bus Station to Florence Bus Station via Atlanta Bus Station in around 23h 25m. Alternatively, you can take a train from Chicago Union Station to Florence Station via Petersburg Amtrak Station in around 27h 9m.

Airlines
Train operators
Bus operators

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Need to know: Greyhound

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