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How to get fromChicago to Florenceby plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, or train

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There are 11 ways to get from Chicago to Florence by plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Myrtle Beach, bus

    best
    1. Fly from Chicago Midway International Airport (MDW) to Myrtle Beach (MYR)plane plane MDW - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    6h 22m

  2. Fly Chicago Midway International Airport to Charleston International Airport, train

    cheapest
    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    8h 25m
    $136–624

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus FlixBus 2512 / ...
    2. Take the bus from Atlanta to Florencebus bus Ses 987 / ...
    21h 15m
    $160–306

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Florence Stationtrain train Palmetto / ...
    27h 9m
    $380–771

  5. Drive 830.4 mi

    1. Drive from Chicago to Florencecar car 830.4 mi
    15h 48m
    $152–219

  6. Fly Chicago O'Hare International Airport to Myrtle Beach, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Myrtle Beach (MYR)plane plane ORD - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    6h 52m

  7. Fly Chicago O'Hare International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Charlotte Douglas International Airport (CLT)plane plane ORD - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florencebus bus
    9h
    $156–460

  8. Fly Chicago Midway International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Charlotte Douglas International Airport (CLT)plane plane MDW - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florencebus bus
    8h 43m
    $146–750

  9. Fly Chicago Midway International Airport to Raleigh-Durham International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Raleigh-Durham International Airport (RDU)plane plane MDW - RDU
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    9h 25m
    $182–360

  10. Fly Chicago O'Hare International Airport to Columbia, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    2. Take the bus from Columbia, SC to Camdenbus bus
    3. Take the bus from Camden to Florencebus bus
    9h 41m
    $212–964

  11. Train, bus

    1. Take the train from Chicago Union Station to Raleigh Union Stationtrain train Floridian
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    28h 33m
    $374–749

Chicago to Florence by bus

Calendar49Weekly Buses
Duration21h 15mAverage Duration
Ticket$160Cheapest Price
See schedules

Questions & Answers

Map of how to get from Chicago to Florence.ExpandLaunch map view
  • Distance: 827.5 mi
  • Duration: 6h 22m

What companies run services between Chicago, IL, USA and Florence, SC, USA?

You can take a bus from Chicago Bus Station to Florence via Atlanta in around 21h 15m. Alternatively, you can take a train from Chicago Union Station to Florence Station via Petersburg Amtrak Station in around 27h 9m.

Airlines
Train operators
Bus operators

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