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How to get fromChicago to Florence Stationby plane, train, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

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There are 12 ways to get from Chicago to Florence Station by plane, train, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Charleston International Airport, train

    best
    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    8h 25m
    $136–624

  2. Fly Chicago O'Hare International Airport to Myrtle Beach, bus, train

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Myrtle Beach (MYR)plane plane ORD - MYR
    2. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    10h 5m
    $124–453

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus Greyhound US0641S / ...
    23h 49m
    $154–297

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Florence Stationtrain train Palmetto / ...
    27h 9m
    $378–777

  5. Drive 830.8 mi

    1. Drive from Chicago to Florence Stationcar car 830.8 mi
    15h 50m
    $152–219

  6. Fly Chicago O'Hare International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Charlotte Douglas International Airport (CLT)plane plane ORD - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    9h 35m
    $144–458

  7. Fly Chicago Midway International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Charlotte Douglas International Airport (CLT)plane plane MDW - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    9h 18m
    $144–748

  8. Fly Chicago O'Hare International Airport to Columbia, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    2. Take the bus from Columbia, SC to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    10h 16m
    $222–1,013

  9. Fly Chicago Midway International Airport to Myrtle Beach, bus, train

    1. Fly from Chicago Midway International Airport (MDW) to Myrtle Beach (MYR)plane plane MDW - MYR
    2. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    9h 35m
    $138–533

  10. Fly Chicago O'Hare International Airport to Piedmont Triad International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Piedmont Triad International Airport (GSO)plane plane ORD - GSO
    2. Take the train from Greensboro to Selma Stationtrain train
    3. Take the train from Selma Station to Florence Stationtrain train
    11h 4m
    $206–805

  11. Fly Chicago Midway International Airport to Raleigh-Durham International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Raleigh-Durham International Airport (RDU)plane plane MDW - RDU
    2. Take the train from Raleigh Union Station to Selma Stationtrain train
    3. Take the train from Selma Station to Florence Stationtrain train
    10h 31m
    $204–417

  12. Train, bus

    1. Take the train from Chicago Union Station to Raleigh Union Stationtrain train Floridian
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    28h 58m
    $370–751

Chicago to Florence Station by train (Amtrak)

Calendar7Weekly Trains
Duration27h 9mAverage Duration
Ticket$378Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Florence Station.ExpandLaunch map view
  • Distance: 867.3 mi
  • Duration: 8h 25m

What companies run services between Chicago, IL, USA and Florence Station, SC, USA?

You can take a bus from Chicago Bus Station to Florence Station via Atlanta Bus Station and Florence Bus Station in around 23h 49m. Alternatively, you can take a train from Chicago Union Station to Florence Station via Petersburg Amtrak Station in around 27h 9m.

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