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How to get fromChicago to Gainesvilleby plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, bus (Flixbus), or bus (Greyhound, Flixbus)

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There are 9 ways to get from Chicago to Gainesville by plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, bus (Flixbus), or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Hartsfield-Jackson Atlanta International Airport, bus

    best
    1. Fly from Chicago Midway International Airport (MDW) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane MDW - ATL
    2. Take the bus from Atlanta to BB Wireless - Gainesvillebus bus
    6h 15m
    $130–330

  2. Bus

    cheapest
    1. Take the bus from Chicago to Atlanta Bus Stationbus bus FlixBus 2512
    2. Take the bus from Atlanta Bus Station to Gainesvillebus bus Greyhound US0670
    17h 47m
    $120–244

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Charlottesvilletrain train Cardinal
    2. Take the train from Charlottesville to Gainesville Stationtrain train Crescent
    32h 13m
    $412–849

  4. Drive 662.6 mi

    1. Drive from Chicago to Gainesvillecar car 662.6 mi
    13h 16m
    $121–175

  5. Fly Chicago O'Hare International Airport to Hartsfield-Jackson Atlanta International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane ORD - ATL
    2. Take the bus from Atlanta to BB Wireless - Gainesvillebus bus
    6h 40m
    $240–510

  6. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    2. Take the bus from Taqueria Guadalajara - Greenville to BB Wireless - Gainesvillebus bus
    7h 35m
    $192–762

  7. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Gainesvillecar car
    7h 7m
    $130–650

  8. Bus via Bloomington

    1. Take the bus from Chicago Bus Station to Bloomingtonbus bus
    2. Take the bus from Bloomington to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to BB Wireless - Gainesvillebus bus
    18h 32m
    $171–349

  9. Bus #2

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Gainesvillebus bus Greyhound US0670
    18h 33m
    $129–238

Chicago to Gainesville by train (Amtrak)

Calendar3Weekly Trains
Duration32h 13mAverage Duration
Ticket$412Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Gainesville.ExpandLaunch map view
  • Distance: 666.5 mi
  • Duration: 6h 15m

What companies run services between Chicago, IL, USA and Gainesville, GA, USA?

You can take a subway from Harrison to Gainesville via 95th, Chicago, Atlanta Bus Station, and Gainesville in around 17h 47m. Alternatively, you can take a train from Chicago Union Station to Gainesville Station via Charlottesville in around 32h 13m.

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Train operators
Bus operators

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